皮质类固醇对慢性阻塞性肺疾病痰液可溶性蛋白酶抑制剂的影响。
Effect of corticosteroids on sputum sol-phase protease inhibitors in chronic obstructive pulmonary disease.
作者信息
Wiggins J, Elliott J A, Stevenson R D, Stockley R A
出版信息
Thorax. 1982 Sep;37(9):652-6. doi: 10.1136/thx.37.9.652.
Abstract
Corticosteroids caused a reduction in the ratio of sol-phase sputum concentration to serum concentration of albumin in 12 patients with chronic obstructive bronchitis, suggesting a reduction in protein transudation. Alpha-1-antitrypsin values followed the same pattern as those of albumin in both the control and treatment periods, confirming the similar behaviour of the two proteins. The alpha 1-antichymotrypsin ratios were on average three times higher than those of albumin in the control period, confirming the presence of local mechanisms in the lung for preferentially concentrating this protein. The sputum-to-serum ratio of alpha 1-antichymotrypsin, however, rose during steroid treatment with the result that there was a selective increase in this protease inhibitor, which may be of potential benefit to such patients.
摘要
皮质类固醇使12例慢性阻塞性支气管炎患者痰液中白蛋白的溶解相浓度与血清浓度之比降低，提示蛋白渗出减少。在对照期和治疗期，α-1抗胰蛋白酶值与白蛋白值呈现相同模式，证实了这两种蛋白质的相似行为。在对照期，α1抗糜蛋白酶与白蛋白的比值平均高出三倍，证实肺部存在优先浓缩该蛋白的局部机制。然而，在类固醇治疗期间，α1抗糜蛋白酶的痰液与血清比值升高，结果是这种蛋白酶抑制剂选择性增加，这可能对此类患者具有潜在益处。
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