Herzog C, Geddes A M
Trans R Soc Trop Med Hyg. 1982;76(6):848-9. doi: 10.1016/0035-9203(82)90123-7.
Chloramphenicol is still very effective for acute enteric fever. A literature survey does not confirm the repeated claims of decreasing efficacy over the past 20 years (not taking into account the R factor mediated resistance noted since 1972/73). However, there have been regional variations in the time needed to achieve defervescence under chloramphenicol treatment since the early 1950s. When comparing alternative antimicrobials with chloramphenicol other criteria apart from clinical efficacy have to be considered, namely, influence on the rate of excretion of the organisms and the relapse rate, ease of administration parenterally, toxicity, cost, and the possible occurrence of resistance to Salmonella typhi or S. paratyphi A/B.
氯霉素对急性肠热症仍然非常有效。一项文献调查并未证实过去20年来反复出现的关于其疗效下降的说法（未考虑自1972/73年以来发现的R因子介导的耐药性）。然而，自20世纪50年代初以来，在氯霉素治疗下实现退热所需的时间存在地区差异。在将替代抗菌药物与氯霉素进行比较时，除了临床疗效外，还必须考虑其他标准，即对病原体排泄率和复发率的影响、胃肠外给药的便利性、毒性、成本以及对伤寒沙门氏菌或副伤寒甲/乙沙门氏菌产生耐药性的可能性。
