Gomez-Reino J, Miller F, Meiselas L
J Lab Clin Med. 1980 Mar;95(3):335-42.
The effect of several LPSs on the thymidine uptake of lymphocytes from patients with RA was investigated. In contrast to normal controls, the mitogenic response to E. coli 026 B6 LPS by lymphocytes from patients with RA was significantly (2p less than 0.05) diminished. This effect was seen with Con A but not with PHA or PWM. No correlation with peripheral B or T cell percentages or with antibody titers to the LPS was found. The response to LPS was dependent on the species and strain of bacterium from which it was isolated.
研究了几种脂多糖对类风湿关节炎患者淋巴细胞摄取胸苷的影响。与正常对照组相比，类风湿关节炎患者淋巴细胞对大肠杆菌026 B6脂多糖的促有丝分裂反应显著减弱（P<0.05）。这种效应在刀豆蛋白A存在时可见，但在植物血凝素或美洲商陆有丝分裂原存在时未见。未发现与外周血B或T细胞百分比或脂多糖抗体滴度相关。对脂多糖的反应取决于分离出该脂多糖的细菌的种类和菌株。
