Azad K, Parkin J M, Court S, Laker M F, Alberti K G
Department of Medicine, University of Newcastle upon Tyne.
Arch Dis Child. 1994 Aug;71(2):108-13. doi: 10.1136/adc.71.2.108.
The prevalence of dyslipidaemia in children with insulin dependent diabetes mellitus (IDDM) and its relation to glycaemic control was studied in a group of 51 diabetic children and a control population of 132 schoolchildren. The prevalence of dyslipidaemia in the fasting state was increased in the diabetic group (39%) compared with control subjects (17%). Serum cholesterol concentration alone was raised in 25% of diabetic subjects while serum cholesterol and triglycerides were raised in 14%, compared with 16% and 0.7% respectively in control subjects. Serum total cholesterol (5.1 v 4.5 mmol/l), low density lipoprotein cholesterol (3.2 v 2.6 mmol/l), non-esterified fatty acids (0.91 v 0.50 mmol/l), and triglycerides (0.94 v 0.76 mmol/l) were higher in diabetic children. Serum total cholesterol, triglycerides, and apolipoprotein (apo)B concentrations increased with worsening control, while serum high density lipoprotein cholesterol and apoA-I concentrations were unaltered. There were also positive correlations between glycated haemoglobin and total cholesterol, triglycerides, and apoB in diabetic children. Thus, abnormalities in circulating lipids are common in young subjects with IDDM but largely disappear if blood glucose concentrations are reasonably controlled.
对51名糖尿病儿童和132名学童组成的对照人群进行研究，以探讨胰岛素依赖型糖尿病（IDDM）患儿血脂异常的患病率及其与血糖控制的关系。与对照组（17%）相比，糖尿病组空腹血脂异常的患病率有所增加（39%）。糖尿病患者中仅血清胆固醇浓度升高的占25%，而血清胆固醇和甘油三酯均升高的占14%，相比之下，对照组分别为16%和0.7%。糖尿病儿童的血清总胆固醇（5.1对4.5 mmol/l）、低密度脂蛋白胆固醇（3.2对2.6 mmol/l）、非酯化脂肪酸（0.91对0.50 mmol/l）和甘油三酯（0.94对0.76 mmol/l）较高。随着控制情况变差，血清总胆固醇、甘油三酯和载脂蛋白（apo）B浓度升高，而血清高密度脂蛋白胆固醇和apoA-I浓度未改变。糖尿病儿童糖化血红蛋白与总胆固醇、甘油三酯和apoB之间也存在正相关。因此，循环脂质异常在IDDM的年轻患者中很常见，但如果血糖浓度得到合理控制，这些异常在很大程度上会消失。
