Ramsell T G, Bartholomew R S, Walker S R
Br J Ophthalmol. 1980 Jan;64(1):43-5. doi: 10.1136/bjo.64.1.43.
Clobetasone butyrate, a new corticosteroid with a high topical activity, has been compared with prednisolone phosphate and a placebo in the treatment of inflammation following cataract extraction. These 2 steroids were more effective in relieving postoperative inflammation than placebo (P less than 0.05), though no obvious clinical differences between the 2 compounds emerged from this investigation. However, a single-blind comparative study against betamethasone phosphate in patients suspected of having steroid-induced glaucoma showed that, while betamethasone phosphate significantly raised intraocular pressure, clobetasone butyrate had only a minimal effect, and this difference was statistically significant (P less than 0.02).
丁酸氯倍他松是一种具有高局部活性的新型皮质类固醇，已将其与磷酸泼尼松龙及安慰剂相比较，用于治疗白内障摘除术后的炎症。这两种类固醇在缓解术后炎症方面比安慰剂更有效（P<0.05），不过从本次研究中未发现这两种化合物之间有明显的临床差异。然而，一项针对疑似患有类固醇性青光眼患者的与磷酸倍他米松的单盲对照研究表明，磷酸倍他米松可显著升高眼压，而丁酸氯倍他松仅有极小的影响，且这种差异具有统计学意义（P<0.02）。
