Longworth D L, Drayer J I, Weber M A, Laragh J H
Clin Pharmacol Ther. 1980 Apr;27(4):544-6. doi: 10.1038/clpt.1980.76.
In untreated patients with essential hypertension, daily sodium intake was reduced from 197 to 70 mEq/day in 82 outpatients and from 124 to 14 mEq/day in 25 patients in a metabolic ward. During the 10 days of sodium restriction 17% of the outpatients and 40% of the inpatients had mean blood pressure decreases of at least 10 mm Hg, but in 17% of the outpatients and 28% of the inpatients mean pressure rose at least 5 mm Hg. Most blood pressure decreases occurred in the group with high-renin hypertension. Our short-term experience suggests that dietary salt deprivation may not be effective treatment for all patients with hypertension and may even be counterproductive in some.
在未经治疗的原发性高血压患者中，82名门诊患者的每日钠摄入量从197毫当量/天降至70毫当量/天，代谢病房的25名患者从124毫当量/天降至14毫当量/天。在限钠的10天里，17%的门诊患者和40%的住院患者平均血压至少下降了10毫米汞柱，但17%的门诊患者和28%的住院患者平均血压至少上升了5毫米汞柱。大多数血压下降发生在高肾素性高血压组。我们的短期经验表明，饮食限盐可能并非对所有高血压患者都有效，甚至在某些患者中可能会适得其反。
