硒和二甲基二十八烷基溴化铵对瑞士-韦伯斯特小鼠疟疾（伯氏疟原虫）疫苗诱导免疫的影响。
Effect of selenium and dimethyl dioctadecyl ammonium bromide on the vaccine-induced immunity of Swiss-Webster mice against malaria (Plasmodium berghei).
作者信息
Desowitz R S, Barnwell J W
出版信息
Infect Immun. 1980 Jan;27(1):87-9. doi: 10.1128/iai.27.1.87-89.1980.
Abstract
The results of the study described in this paper demonstrate that selenium, administered in drinking water, potentiates the protective effect of a killed Plasmodium berghei vaccine for Swiss-Webster mice. We also report that a vaccine consisting of P. berghei antigen combined with the adjuvant dimethyl dioctadecyl ammonium bromide conferred a significantly high level of protective immunity. An additive effect was shown in that the greatest degree of protection was afforded to the group of mice maintained on selenium and vaccinated with antigen-dimethyl dioctadecyl ammonium bromide. Almost all of the animals treated in this manner survived the challenging infection, the course of which was typically of a transitory parasitemia not exceeding 10% at the peak.
摘要
本文所述研究结果表明，给瑞士韦伯斯特小鼠饮用含硒的水，可增强灭活的伯氏疟原虫疫苗的保护作用。我们还报告称，由伯氏疟原虫抗原与佐剂二甲基二十八烷基溴化铵组成的疫苗可赋予显著高水平的保护性免疫。结果显示存在相加效应，即对饮用含硒水并接种抗原 - 二甲基二十八烷基溴化铵的小鼠组给予了最大程度的保护。几乎所有以这种方式处理的动物在受到感染挑战后存活下来，感染过程通常表现为短暂的寄生虫血症，峰值时不超过10%。
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