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论恶性黑色素瘤的组织学诊断与预后

On the histological diagnosis and prognosis of malignant melanoma.

作者信息

Levene A

出版信息

J Clin Pathol. 1980 Feb;33(2):101-24. doi: 10.1136/jcp.33.2.101.

DOI:10.1136/jcp.33.2.101
PMID:6988460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1146004/
Abstract

This review deals with difficulties of diagnosis in cutaneous malignant melanoma encountered by histopathologists of variable seniority and is based on referred material at The Royal Marsden Hospital over a 20-year period and on the experience of more than two-and-a-half thousand cases referred to The World Health Organisation Melanoma Unit which I reviewed when chairman of the Pathologists' Committee. Though there is reference to the differential diagnosis of primary and metastatic tumour, the main concern is with establishing the diagnosis of primary melanoma to the exclusion of all other lesions. An appendix on recommended diagnostic methods in cutaneous melanomas is included.

摘要

本综述探讨了不同资历的组织病理学家在诊断皮肤恶性黑色素瘤时所遇到的困难，其依据是皇家马斯登医院20年间的转诊资料，以及我在担任病理学家委员会主席时审阅的提交给世界卫生组织黑色素瘤小组的两千五百多例病例的经验。虽然文中提到了原发性肿瘤和转移性肿瘤的鉴别诊断，但主要关注的是排除所有其他病变，确立原发性黑色素瘤的诊断。文中还包括了关于皮肤黑色素瘤推荐诊断方法的附录。

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本文引用的文献

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Melanomas of childhood.儿童黑色素瘤
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Am J Pathol. 1949 Nov;25(6):1117-55, incl 4 pl.
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My conception of cellular nevi.我对细胞痣的概念。
嵌套性黑色素瘤
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Primary amelanotic malignant melanoma of the esophagus: a case report.原发性食管无色素性恶性黑色素瘤：一例报告
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Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish.ERK1/2-丝裂原活化蛋白激酶信号传导对维持斑马鱼中致癌性GNAQQ209P驱动的葡萄膜黑色素瘤的贡献极小。
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