Giercksky K E, Danielsen S, Garberg O, Grüner O P, Holter O, Johnson J A, Nygaard K, Ofstad E, Stadaas J, Viddal K O
Ann Surg. 1982 Feb;195(2):227-31. doi: 10.1097/00000658-198202000-00019.
Antimicrobial prophylaxis with agents active against aerobic and anaerobic micro-organisms leads to a significant reduction of infectious complications following colorectal surgery. A single dose (1600 mg) of tinidazole (a nitroimidazole derivate) and doxycycline (400 mg) will provide serum and tissue values well above minimum inhibitory concentration (MIC) values for more than 24 hours. To reduce the unwanted side effects and cost of prolonged antimicrobial prophylaxis, a prospective controlled clinical multicenter study comparing the effect of a single dose before operation of tinidazole and doxycycline to five days of prophylaxis before operation in 234 patients undergoing elective colorectal surgery was undertaken. Six patients given a single dose of prophylaxis before operation (n = 118) developed infectious complication (5.1%). Prolongation of prophylaxis before operation for four days after operation (n = 116) did not lead to any further reduction of infectious complications. A single dose of tinidazole and doxycycline before operation is a simple and effective prophylaxis against infectious complications following elective colorectal surgery.
使用对需氧和厌氧微生物有效的药物进行抗菌预防可显著降低结直肠手术后的感染并发症。单剂量（1600毫克）的替硝唑（一种硝基咪唑衍生物）和多西环素（400毫克）可使血清和组织中的药物浓度在24小时以上保持在远高于最低抑菌浓度（MIC）的水平。为了减少长期抗菌预防带来的不良副作用和成本，我们开展了一项前瞻性对照临床多中心研究，比较234例择期结直肠手术患者术前单次使用替硝唑和多西环素与术前进行五天预防的效果。术前接受单次预防用药的6例患者（n = 118）出现了感染并发症（5.1%）。术后将预防用药延长至术后四天（n = 116）并未导致感染并发症进一步减少。术前单次使用替硝唑和多西环素是预防择期结直肠手术后感染并发症的一种简单有效的方法。
