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产肠毒素和侵袭性大肠杆菌作为芬兰儿童腹泻的病因

Enterotoxigenic and invasive Escherichia coli as causes of childhood diarrhoea in Finland.

作者信息

Mäki M, Vesikari T, Grönroos P

出版信息

Acta Paediatr Scand. 1980 Mar;69(2):219-24. doi: 10.1111/j.1651-2227.1980.tb07064.x.

Abstract

E. coli was considered as the possible aetiologic agent in 16 cases (5.7%) of 283 hospital admissions for diarrhoea. One invasive strain was isolated from a case with exudative diarrhoea. Four heat-labile (LT) enterotoxin-producing strains were found in relatively mild cases of diarrhoea. Eleven strains belonged to "classic" pathogenic serotypes (EPEC); 9 of these were endemic cases and 2 associated with travel. Of the latter, 1 strain (078) was also found to produce heat-stable (ST) enterotoxin detectable by infant mouse assay. Although EPEC are now found much less frequently than 20 years ago, E. coli as a whole may still be the most common bacterial aetiology of childhood diarrhoea in Finland.

摘要

在283例因腹泻入院的病例中,有16例(5.7%)认为大肠杆菌是可能的病原体。从1例渗出性腹泻病例中分离出1株侵袭性菌株。在相对较轻的腹泻病例中发现了4株产不耐热(LT)肠毒素的菌株。11株属于“经典”致病血清型(EPEC);其中9例为地方性病例,2例与旅行有关。在后者中,还发现1株(078)产生可通过幼鼠试验检测到的耐热(ST)肠毒素。尽管现在EPEC的发现频率比20年前低得多,但总体而言,大肠杆菌可能仍是芬兰儿童腹泻最常见的细菌病因。

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