呋喃妥因对植物线粒体中脱氧核糖核酸合成的影响。
The effect of nitrofurantoin on deoxyribonucleic acid synthesis in plant mitochondria.
作者信息
Palit S, Goswami B B, Dube D K
出版信息
Biochem J. 1980 Jan 15;186(1):325-9. doi: 10.1042/bj1860325.
Abstract
Nitrofurantoin (1-([(5-nitrofuran-2-yl)methylene]amino)imidazolidine-2,4-dione), a widely used drug and also a well-known bacterial mutagen, inhibits DNA synthesis in mitochondria from 48 h etiolated seedlings of Vigna sinensis (Linn.) Savi (snake bean). The effect appears at the level of the uptake of radioactive deoxynucleoside triphosphates by the plant mitochondria. Nitrofurantoin does not inhibit DNA synthesis in vitro by homogeneous Escherichia coli DNA polymerase I and DNA polymerase from avian-myeloblastosis virus. No specific nitroreductase activity could be detected in mitochondria.
摘要
呋喃妥因（1-([(5-硝基呋喃-2-基)亚甲基]氨基)咪唑烷-2,4-二酮）是一种广泛使用的药物，也是一种著名的细菌诱变剂，它能抑制豇豆（Vigna sinensis (Linn.) Savi，蛇豆）48小时黄化幼苗线粒体中的DNA合成。这种作用出现在植物线粒体摄取放射性脱氧核苷三磷酸的水平上。呋喃妥因在体外不抑制纯大肠杆菌DNA聚合酶I和禽成髓细胞瘤病毒DNA聚合酶的DNA合成。在线粒体中未检测到特异性硝基还原酶活性。
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本文引用的文献
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The action of nitrofurantoin: inhibition of growth of Escherichia coli K 12 and of IPTG-induced beta-galaotosidase synthesis.呋喃妥因的作用：抑制大肠杆菌K12的生长及异丙基-β-D-硫代半乳糖苷（IPTG）诱导的β-半乳糖苷酶的合成。
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Inhibition of mitochondrial protein synthesis by nitrofurantoin in rat and goat liver.呋喃妥因对大鼠和山羊肝脏线粒体蛋白质合成的抑制作用。
Biochem Pharmacol. 1974 Jan 15;23(2):470-2. doi: 10.1016/0006-2952(74)90442-0.
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Protein synthesis in vitro in a system from plant mitochondria.利用植物线粒体系统进行体外蛋白质合成。
Biochem J. 1973 Jul;134(3):815-6. doi: 10.1042/bj1340815.
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Erroneous base-pairing induced by a chemical carcinogen during DNA synthesis.DNA合成过程中化学致癌物诱导的错误碱基配对。
Nature. 1974 Nov 29;252(5482):414-6. doi: 10.1038/252414a0.
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"Activation" of nitrofurazone in animal tissues.呋喃西林在动物组织中的“活化”
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Purification and detection of reverse transcriptase in viruses and cells.病毒和细胞中逆转录酶的纯化与检测。
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Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.在沙门氏菌/微粒体试验中作为诱变剂的致癌物检测：300种化学物质的测定：讨论
Proc Natl Acad Sci U S A. 1976 Mar;73(3):950-4. doi: 10.1073/pnas.73.3.950.
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Differential heat sensitivity of mammalian DNA polymerases.哺乳动物DNA聚合酶的热敏感性差异
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