Hill T L, Eisenberg E
Biophys Chem. 1980 Apr;11(2):271-81. doi: 10.1016/0301-4622(80)80030-5.
In a previous paper, equilibrium ocnstants for the binding of myosin fragments onto F-actin were assumed known and the statistical problems encountered when the actin sites are occupied to an arbitrary fractional extent were analyzed. The object of the present paper is to attempt to understand the observed order of magnitude of these equilibrium constants in terms of the statistical mechanical degrees of freedom involved. That is, we examine here the equilibrium constants themselves rather than the statistical consequences of the equilibrium constants. The treatment given amounts to a semi-quantitative sketch or outline of the problem. Structural details are much too uncertain to warrant a careful and rigorous treatment at this time. But the discussion suffices to establish the essential qualitative features of the problem. The procedure used is to examine the important equilibrium constants, one at a time, in terms of the factors (partition functions) that contribute to each constant, together with numerical estimates for these factors.
在之前的一篇论文中，假定肌球蛋白片段与F - 肌动蛋白结合的平衡常数已知，并分析了肌动蛋白位点被占据到任意分数程度时遇到的统计问题。本文的目的是尝试根据所涉及的统计力学自由度来理解这些平衡常数所观察到的数量级。也就是说，我们在这里研究平衡常数本身，而不是平衡常数的统计结果。所给出的处理相当于对该问题的半定量概述。目前结构细节过于不确定，无法进行仔细而严格的处理。但该讨论足以确立该问题的基本定性特征。所采用的方法是逐一根据对每个常数有贡献的因素（配分函数）来研究重要的平衡常数，并对这些因素进行数值估计。
