Bland R D, Kim M H, Light M J, Woodson J L
Crit Care Med. 1980 May;8(5):275-80. doi: 10.1097/00003246-198005000-00001.
Twenty-four preterm infants with respiratory failure from severe hyaline membrane disease (HMD) received mechanical ventilation at high respiratory frequencies. The average birthweight of the infants was 1244 +/- 301 g, and 7 babies weighed less than 1000 g. The average gestational age was 30 +/- 2 weeks, and 6 infants were born at 28 weeks or less. The method of ventilation included (1) respiratory frequencies of 60--110/min, sometimes with brief manual ventilation at more rapid rates, (2) peak inflation pressures (PIP) of less than 35 cm H2O, (3) inspiratory durations of 0.15--0.25 sec, (4) positive end-expiratory pressure (PEEP) of 4--9 cm H2O, and (5) weaning from mechanical ventilation by reducing tidal volume until peak inflation pressure (PIP) reached 20--25 cm H2O, whereupon respiratory frequency was decreased. PaCO2 was kept at 30--40 torr and PaO2 at 60--80 torr. Of the infants, 22 survived (92%) with few major complications.
24例患有严重透明膜病（HMD）所致呼吸衰竭的早产儿接受了高呼吸频率的机械通气。这些婴儿的平均出生体重为1244±301克，7名婴儿体重不足1000克。平均胎龄为30±2周，6名婴儿在28周或更早出生。通气方法包括：（1）呼吸频率为60-110次/分钟，有时以更快的频率进行短暂手动通气；（2）吸气峰压（PIP）小于35厘米水柱；（3）吸气持续时间为0.15-0.25秒；（4）呼气末正压（PEEP）为4-9厘米水柱；（5）通过减少潮气量直至吸气峰压（PIP）达到20-25厘米水柱来撤离机械通气，随后降低呼吸频率。将PaCO2维持在30-40托，PaO2维持在60-80托。这些婴儿中，22例存活（92%），几乎没有严重并发症。
