Jacoby R O, Bhatt P N, Schwartz A
J Infect Dis. 1980 May;141(5):617-24. doi: 10.1093/infdis/141.5.617.
C3H/RV mice, which are genetically resistant to lethal flaviviral infection were susceptible to lethal challenge with Banzi virus after they were given rabbit antiserum to mouse thymocytes. Congenic C3H/He mice, which are genetically susceptible to lethal flaviviral infection, were protected from lethal challenge with Banzi virus by adoptive immunization with splenic cells from syngeneric or congenic donor mice infected with live virus, as measured by amelioration of clinical disease, death rates, and viral replication. Protection was dependent on thymus cells; mice given immune splenic cells treated with rabbit antiserum to mouse brain and complement had high death rates. Transfer of protection was dependent on time and the dosage of splenic cells. Immune splenic cells from c3h/rv donors were, on a cell-for-cell basis, more effective than immune splenic cells from C3H/He donors in preventing viral replication, encephalitis, and death in C3H/He recipients.
C3H/RV小鼠对致死性黄病毒感染具有遗传抗性，但在给予兔抗小鼠胸腺细胞血清后，对班齐病毒的致死性攻击变得易感。同基因的C3H/He小鼠对致死性黄病毒感染具有遗传易感性，通过用感染活病毒的同基因或同系供体小鼠的脾细胞进行过继免疫，可使其免受班齐病毒的致死性攻击，这通过临床疾病的改善、死亡率和病毒复制来衡量。保护作用依赖于胸腺细胞；给予用兔抗小鼠脑血清和补体处理的免疫脾细胞的小鼠死亡率很高。保护作用的转移依赖于时间和脾细胞的剂量。在预防C3H/He受体的病毒复制、脑炎和死亡方面，来自C3H/RV供体的免疫脾细胞在逐个细胞的基础上比来自C3H/He供体的免疫脾细胞更有效。
