Vogel L C, Boyer K M, Gadzala C A, Gotoff S P
J Pediatr. 1980 Jun;96(6):1047-51. doi: 10.1016/s0022-3476(80)80639-1.
Immunoglobulin G antibody against the four major serotypes of group B streptococcus was measured by indirect immunofluorescence in the sera of 200 consecutive pregnant women seen in the obstetric screening clinic of an urban teaching hospital. Antibody was detectable in 26% of undiluted sera against serotype Ia, 52% against serotype Ib, 82% against serotype II, and 45% against serotype III. Only 9% had antibody against all four GBS types. When serotype-specific antibody prevalences in 108 women with GBS vaginal colonization were compared with prevalences in noncolonized women, only women colonized with GBS type Ia were more likely to have antibody against Ia than noncolonized women. Antibody prevalences in sera from 54 mothers whose infants developed invasive GBS disease were significantly lower than those in colonized or noncolonized women. Since low titers of IF antibody to GBS III were present in some sera from mothers of infected infants, the data were analyzed based on IF antibody titers associated with passive protection in a chick embryo model of GBS septicemia. None of the sera from mothers of infected infants had antibody levels associated with chick embryo protection. Less than 10% of women had titers associated with chick embryo protection. These data suggest that the majority of pregnant women lack immunity to GBS, regardless of colonization status.
在一家城市教学医院的产科筛查门诊，对连续就诊的200名孕妇血清采用间接免疫荧光法检测了抗B族链球菌四种主要血清型的免疫球蛋白G抗体。在未稀释血清中，26%可检测到抗Ia血清型抗体，52%可检测到抗Ib血清型抗体，82%可检测到抗II血清型抗体，45%可检测到抗III血清型抗体。仅有9%的孕妇具有针对所有四种GBS血清型的抗体。当比较108名GBS阴道定植女性的血清型特异性抗体患病率与未定植女性的患病率时，只有定植GBS Ia型的女性比未定植女性更有可能具有抗Ia抗体。54名婴儿发生侵袭性GBS疾病的母亲血清中的抗体患病率显著低于定植或未定植女性。由于感染婴儿母亲的一些血清中存在低滴度的抗GBS III型IF抗体，因此基于在GBS败血症鸡胚模型中与被动保护相关的IF抗体滴度对数据进行了分析。感染婴儿母亲的血清中均没有与鸡胚保护相关的抗体水平。不到10%的女性具有与鸡胚保护相关的滴度。这些数据表明，大多数孕妇对GBS缺乏免疫力，无论其定植状态如何。
