Fay D, Baird I M, Aguirre A, Haegren V, Werling K, Bell T W
JAMA. 1980 Jun 13;243(22):2311-3.
Lungs from 224 patients, obtained at autopsy, were examined for Legionella pneumophila by fluorescent antibody (FA) staining. Of 121 patients who died with pneumonia, L pneumophila was present in eight cases (6.6%). (Two of the eight patients exhibited no important respiratory symptoms or fever, although pneumonia contributed considerably to their deaths. Preexisting underlying disease was present in all cases. Legionnaires' disease (LD), endemic in the central Ohio area, may cause up to 3.6% of the nosocomial pneumonias at the study site. Application of the local incidence of LD to the number of annual adult deaths in the United States indicates that many LD-associated deaths may occur each year. The study shows the importance of using the FA and Dieterle stains during routine pathological examination of lung tissue, especially from compromised hosts in endemic areas.
对224例尸检获得的患者肺部组织进行荧光抗体（FA）染色，以检测嗜肺军团菌。在121例死于肺炎的患者中，有8例（6.6%）检测到嗜肺军团菌。（这8例患者中有2例没有明显的呼吸道症状或发热，尽管肺炎对其死亡有很大影响。所有病例均存在基础疾病。俄亥俄州中部地区流行的军团病（LD）可能导致研究地点高达3.6%的医院获得性肺炎。将LD的当地发病率应用于美国每年的成人死亡人数表明，每年可能发生许多与LD相关的死亡。该研究表明在对肺组织进行常规病理检查时，尤其是对流行地区免疫功能低下宿主的肺组织检查时，使用FA和Dieterle染色的重要性。
