Schambelan M, Sebastian A, Biglieri E G
Kidney Int. 1980 Jan;17(1):89-101. doi: 10.1038/ki.1980.11.
Our findings indicate that hypoaldosteronism occurs commonly (23/31 patients) in hyperkalemic patients with chronic renal insufficiency and that the deficiency of aldosterone contributes to the pathogenesis of the hyperkalemia. In most patients (83%), hypoaldosteronism could be accounted for by deficient renal secretion of renin, but in some patients (17%) overt renin deficiency did not appear to be present, and therefore other (unidentified) causes of aldosterone deficiency must be invoked. The results also indicate that the urinary excretion rate of aldosterone secretion rate in this group of patients.
我们的研究结果表明，低醛固酮血症在慢性肾功能不全的高钾血症患者中很常见（31例患者中有23例），且醛固酮缺乏导致了高钾血症的发病机制。在大多数患者（83%）中，低醛固酮血症可归因于肾素分泌不足，但在一些患者（17%）中，并未出现明显的肾素缺乏，因此必须考虑醛固酮缺乏的其他（未明确的）原因。结果还表明了该组患者醛固酮分泌率的尿排泄率。
