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相似文献

1
Synthesis of human plasminogen by the liver.肝脏合成人纤溶酶原。
Science. 1980 May 30;208(4447):1036-7. doi: 10.1126/science.6990488.
2
Human C'3: evidence for the liver as the primary site of synthesis.人补体C3：肝脏作为主要合成部位的证据。
Science. 1969 Jan 17;163(3864):286-8. doi: 10.1126/science.163.3864.286.
3
Definition of the transcription initiation site of human plasminogen gene in liver and non hepatic cell lines.
Biochem Biophys Res Commun. 1990 Dec 31;173(3):1013-8. doi: 10.1016/s0006-291x(05)80887-3.
4
Biosynthesis of plasminogen by the perfused rat liver.灌注大鼠肝脏中纤溶酶原的生物合成。
J Lab Clin Med. 1985 Mar;105(3):368-73.
5
Expression of apolipoprotein[a] and plasminogen mRNAs in cynomolgus monkey liver and extrahepatic tissues.食蟹猴肝脏和肝外组织中载脂蛋白[a]和纤溶酶原mRNA的表达
J Lipid Res. 1996 Sep;37(9):2029-40.
6
Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease.酒精对肝脏纤溶平衡的直接影响：对酒精性肝病的意义。
J Hepatol. 2008 Apr;48(4):614-27. doi: 10.1016/j.jhep.2007.12.015. Epub 2008 Jan 29.
7
Production and release of plasminogen by isolated perfused rat liver.离体灌注大鼠肝脏纤溶酶原的产生与释放
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6837-40. doi: 10.1073/pnas.77.11.6837.
8
Genetic polymorphism of human plasminogen.人纤溶酶原的基因多态性
Am J Hum Genet. 1980 Sep;32(5):681-9.
9
Expression and induction by IL-6 of the normal and variant genes for human plasminogen.人纤溶酶原正常基因和变异基因的表达及IL-6对其的诱导作用
Biochem Biophys Res Commun. 1997 Jan 3;230(1):129-32. doi: 10.1006/bbrc.1996.5909.
10
Polymorphism of the plasminogen (PLG) system in Cádiz Province, southern Spain.
J Forensic Sci. 1991 Jan;36(1):226-9.

引用本文的文献

1
Plasminogen deficiency reduces disease severity and immune responses in enterovirus A71-infected mice.纤溶酶原缺乏可减轻肠道病毒A71感染小鼠的疾病严重程度并降低免疫反应。
Microbiol Spectr. 2025 Jul;13(7):e0331124. doi: 10.1128/spectrum.03311-24. Epub 2025 May 16.
2
Repurposing tranexamic acid as an anticancer drug: a systematic review and meta-analysis.将氨甲环酸重新用作抗癌药物：一项系统评价和荟萃分析。
J Cancer Res Clin Oncol. 2025 May 9;151(5):157. doi: 10.1007/s00432-025-06185-y.
3
Plasminogen missense variants and their involvement in cardiovascular and inflammatory disease.纤溶酶原错义变体及其与心血管和炎症性疾病的关联。
Front Cardiovasc Med. 2024 Jun 25;11:1406953. doi: 10.3389/fcvm.2024.1406953. eCollection 2024.
4
Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Disease.尿纤溶酶原作为人类肾小球疾病疾病进展的标志物。
Am J Kidney Dis. 2024 Aug;84(2):205-214.e1. doi: 10.1053/j.ajkd.2024.01.520. Epub 2024 Mar 5.
5
Tale of two systems: the intertwining duality of fibrinolysis and lipoprotein metabolism.两个系统的故事：纤溶与脂蛋白代谢的交织双重性。
J Thromb Haemost. 2023 Oct;21(10):2679-2696. doi: 10.1016/j.jtha.2023.08.004. Epub 2023 Aug 12.
6
Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis.爱泼斯坦-巴尔病毒相关噬血细胞性淋巴组织细胞增生症的血浆外泌体蛋白质组学模式
Front Microbiol. 2022 Apr 6;13:821311. doi: 10.3389/fmicb.2022.821311. eCollection 2022.
7
Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors.纤溶酶原通过促进骨膜间充质祖细胞的功能来调节骨折修复。
J Bone Miner Res. 2021 Nov;36(11):2229-2242. doi: 10.1002/jbmr.4423. Epub 2021 Sep 8.
8
A large deletion in the Plasminogen gene is associated with ligneous membranitis in a Maltese dog.纤溶酶原基因大片段缺失与一只马耳他犬的木样结膜炎相关。
Anim Genet. 2021 Oct;52(5):767-771. doi: 10.1111/age.13130. Epub 2021 Aug 9.
9
Plasminogen Activators in Neurovascular and Neurodegenerative Disorders.神经血管和神经退行性疾病中的纤溶酶原激活剂
Int J Mol Sci. 2021 Apr 22;22(9):4380. doi: 10.3390/ijms22094380.
10
Plasmin and Plasminogen System in the Tumor Microenvironment: Implications for Cancer Diagnosis, Prognosis, and Therapy.肿瘤微环境中的纤溶酶和纤溶酶原系统：对癌症诊断、预后及治疗的意义
Cancers (Basel). 2021 Apr 12;13(8):1838. doi: 10.3390/cancers13081838.

本文引用的文献

1
IMMUNOSUPPRESSION AFTER EXPERIMENTAL AND CLINICAL HOMOTRANSPLANTATION OF THE LIVER.实验性及临床肝脏同种移植后的免疫抑制
Ann Surg. 1964 Sep;160(3):411-39. doi: 10.1097/00000658-196409000-00007.
2
PRODUCTION OF MEMBERS OF THE BLOOD COAGULATION AND FIBRINOLYSIN SYSTEMS BY THE ISOLATED PERFUSED LIVER.
Proc Soc Exp Biol Med. 1964 May;116:69-72. doi: 10.3181/00379727-116-29161.
3
Cellular localization of profibrinolysin (plasminogen).纤维蛋白溶酶原（纤溶酶原）的细胞定位
Blood. 1963 Mar;21:306-21.
4
Plasma and tissue proteins produced by non-hepatic rat organs as studied with lysine-epsilon-C14; gamma globulins the chief plasma protein fraction produced by non-hepatic tissues.用赖氨酸-ε-C14研究大鼠非肝脏器官产生的血浆和组织蛋白；γ球蛋白是非肝脏组织产生的主要血浆蛋白组分。
J Exp Med. 1954 Feb;99(2):133-53. doi: 10.1084/jem.99.2.133.
5
Synthesis of all plasma protein fractions except gamma globulins by the liver; the use of zone electrophoresis and lysine-epsilon-C14 to define the plasma proteins synthesized by the isolated perfused liver.肝脏合成除γ球蛋白外的所有血浆蛋白组分；使用区带电泳和赖氨酸-ε-C14来确定离体灌注肝脏合成的血浆蛋白。
J Exp Med. 1954 Feb;99(2):125-32. doi: 10.1084/jem.99.2.125.
6
Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, alpha 1-antitrypsin, C8, and factor B.关于血浆蛋白（包括血清类黏蛋白、转铁蛋白、α1-抗胰蛋白酶、补体C8和B因子）在肝脏中体内合成的研究。
Clin Immunol Immunopathol. 1980 May;16(1):84-9. doi: 10.1016/0090-1229(80)90169-5.
7
[Studies on the fibrinolytic activity of red blood cells. I. Fibrinolytic activities of bone marrow red blood cells and venous red blood cells].[红细胞纤溶活性的研究。I. 骨髓红细胞和静脉红细胞的纤溶活性]
Nihon Ketsueki Gakkai Zasshi. 1966 Nov;29(6):910-27.
8
Fibrinolytic activity of leucocytes in smears of bone marrow and peripheral blood.骨髓和外周血涂片白细胞的纤溶活性
Scand J Haematol. 1968;5(2):129-37. doi: 10.1111/j.1600-0609.1968.tb01727.x.
9
Purification of plasminogen from human granulocytes using DEAE-Sephadex column chromatography.使用DEAE-葡聚糖凝胶柱色谱法从人粒细胞中纯化纤溶酶原。
Biochim Biophys Acta. 1968 Jan 22;154(1):91-5. doi: 10.1016/0005-2795(68)90262-6.
10
Low plasminogen levels and liver disease.低纤溶酶原水平与肝脏疾病
Am J Clin Pathol. 1969 Dec;52(6):661-5. doi: 10.1093/ajcp/52.6.661.

肝脏合成人纤溶酶原。

Synthesis of human plasminogen by the liver.

作者信息

Raum D, Marcus D, Alper C A, Levey R, Taylor P D, Starzl T E

出版信息

Science. 1980 May 30;208(4447):1036-7. doi: 10.1126/science.6990488.

DOI:10.1126/science.6990488
PMID:6990488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2981173/
Abstract

Genetic types of plasminogen were determined from a donor and a recipient before and after hepatic homotransplantation. Examination of the plasminogen types demonstrated that the liver is the principal site of synthesis of human plasminogen.

摘要

在肝脏同种异体移植前后，对一名供体和一名受体的纤溶酶原基因类型进行了测定。对纤溶酶原类型的检测表明，肝脏是人类纤溶酶原的主要合成部位。