Ritter M A, Morris R J
Immunology. 1980 Jan;39(1):85-91.
The cell surface differentiation antigen, Thy-1, was demonstrated by immunofluorescence to be associated with collagen-based connective tissue (mainly basement membrane) around some blood vessels in rat lymphoid organs. This association is highly selective: only certain types of blood vessel within a given lymphoid organ were found to be Thy-1+; and different lymphoid organs (thymus, bone marrow, lymph node and spleen) had characteristic differences in the types of blood vessel that bear Thy-1. In lymph node and spleen the vessels that were Thy-1+ were those involved in lymphocyte recirculation and homing (post-capillary venules and arterioles of white pulp); the possibility that Thy-1 may function in mediating selective adhesion of small lymphocytes to extracellular substrates during recirculation is discussed.
通过免疫荧光法证实，细胞表面分化抗原Thy-1与大鼠淋巴器官中一些血管周围的胶原性结缔组织（主要是基底膜）相关联。这种关联具有高度选择性：在给定的淋巴器官中，仅发现特定类型的血管是Thy-1阳性；不同的淋巴器官（胸腺、骨髓、淋巴结和脾脏）在带有Thy-1的血管类型上具有特征性差异。在淋巴结和脾脏中，Thy-1阳性的血管是参与淋巴细胞再循环和归巢的血管（毛细血管后微静脉和白髓小动脉）；文中讨论了Thy-1在介导再循环过程中小淋巴细胞与细胞外基质的选择性黏附中发挥作用的可能性。
