Threlfall E J, Ward L R, Ashley A S, Rowe B
Br Med J. 1980 May 17;280(6225):1210-1. doi: 10.1136/bmj.280.6225.1210.
Multiresistant strains of Salmonella typhimurium phage types 204 and 193 appeared in calves in 1977 and then spread epidemically in cattle. Food poisoning is the main route by which drug-resistant strains from cattle are spread to man, and by the end of 1979 these two multiresistant strains had been identified in 290 cases of human salmonellosis in Britain. Trimethoprim-resistant S typhimurium were rare until a strain of a new phage type, designated type 204c, spread in cattle in 1979. All isolations of type 204c were trimethoprim resistant. Trimethoprim had been used to treat cattle and this usage has probably contributed to the establishment of type 204c and the increased incidence of trimethoprim-resistant strains. The responsibility to prevent or control drug resistance in bovine S typhimurium lies with the veterinary profession, and more stringent regulatiions governing the use of antibiotics in animals bred for food may be necessary.
鼠伤寒沙门氏菌204型和193型的多重耐药菌株于1977年出现在犊牛中，随后在牛群中流行传播。食物中毒是牛群中的耐药菌株传播给人类的主要途径，到1979年底，在英国290例人类沙门氏菌病病例中已发现这两种多重耐药菌株。耐甲氧苄啶的鼠伤寒沙门氏菌很少见，直到1979年一种新的噬菌体类型（称为204c型）菌株在牛群中传播开来。所有分离出的204c型菌株都耐甲氧苄啶。甲氧苄啶曾被用于治疗牛，这种使用可能促成了204c型菌株的出现以及耐甲氧苄啶菌株发病率的增加。预防或控制牛源鼠伤寒沙门氏菌耐药性的责任在于兽医行业，可能有必要对用于食用动物养殖的抗生素使用制定更严格的规定。
