农场动物肠道细菌菌群中对甲氧苄啶耐药性的调查。
A survey of trimethoprim resistance in the enteric bacterial flora of farm animals.
作者信息
West B, White G
出版信息
J Hyg (Lond). 1979 Jun;82(3):481-8. doi: 10.1017/s0022172400054000.
Abstract
For 29 months the Veterinary Investigation Centres, covering the whole of Great Britain, forwarded trimethoprim-resistant gram negative enteric bacteria to the Wellcome Research Laboratories. These were examined for degree of resistance, presence and type of R factors. Trimethoprim resistance was found in 0.6% of the total number of strains examined by the Veterinary Investigation Centres. Trimethoprim R factors were demonstrated in one quarter of the resistant strains, and R factors were found in two strains of Salmonella typhimurium. It was concluded that while the incidence of trimethoprim resistance revealed by the survey gave no cause for alarm, the detection of resistant strains, and particularly R factors, indicated that the drug should continue to be used only for specific therapeutic purposes.
摘要
在29个月的时间里，覆盖整个英国的兽医调查中心将耐甲氧苄啶的革兰氏阴性肠道细菌送交威康研究实验室。对这些细菌进行了耐药程度、R因子的存在情况及类型的检查。在兽医调查中心检测的菌株总数中，发现0.6%的菌株对甲氧苄啶耐药。在四分之一的耐药菌株中证实存在甲氧苄啶R因子，并且在两株鼠伤寒沙门氏菌中发现了R因子。得出的结论是，虽然调查显示的甲氧苄啶耐药发生率无需引起恐慌，但耐药菌株尤其是R因子的检测表明，该药物应继续仅用于特定的治疗目的。
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