用甲氧苄啶-磺胺嘧啶和安慰剂治疗非淋菌性尿道炎。一项双盲伴侣对照研究。
Treatment of nongonococcal urethritis with trimethoprim-sulphadiazine and with placebo. A double-blind partner-controlled study.
作者信息
Paavonen J, Kousa M, Saikku P, Vartiainen E, Kanerva L, Lassus A
出版信息
Br J Vener Dis. 1980 Apr;56(2):101-4. doi: 10.1136/sti.56.2.101.
The effect of sulphadiazine and trimethoprim (T-S) was compared with that of a placebo in the treatment of 75 men with nongonococcal urethritis (NGU) and their female sexual partners. Forty (53%) men and 30 (40%) women had positive culture results for Chlamydia trachomatis before treatment was started. Thirty-four patients of each sex received active treatment. Of these, 19 men and 15 women had positive culture results for C trachomatis before treatment with T-S and one of each sex had a positive culture result after treatment. C trachomatis had been isolated in 21 men and 15 women before treatment with placebo. At follow up four weeks after treatment had been started, 16 men and 15 women still harboured C trachomatis. Five of the chlamydia-positive patients treated with placebo developed complications (epididymitis, arthritis, or salpingitis) so the trial was discontinued.
在治疗75例非淋菌性尿道炎（NGU）男性患者及其女性性伴侣时，对磺胺嘧啶和甲氧苄啶（T-S）与安慰剂的疗效进行了比较。在开始治疗前，40名（53%）男性和30名（40%）女性沙眼衣原体培养结果呈阳性。每种性别各有34例患者接受了积极治疗。其中，19名男性和15名女性在接受T-S治疗前沙眼衣原体培养结果呈阳性，每种性别各有1例在治疗后培养结果呈阳性。在接受安慰剂治疗前，21名男性和15名女性分离出了沙眼衣原体。在开始治疗四周后的随访中，16名男性和15名女性仍携带沙眼衣原体。5名接受安慰剂治疗的衣原体阳性患者出现了并发症（附睾炎、关节炎或输卵管炎），因此试验停止。
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