Treatment of nongonococcal urethritis with trimethoprim-sulphadiazine and with placebo. A double-blind partner-controlled study.
作者信息
Paavonen J, Kousa M, Saikku P, Vartiainen E, Kanerva L, Lassus A
出版信息
Br J Vener Dis. 1980 Apr;56(2):101-4. doi: 10.1136/sti.56.2.101.
Abstract
The effect of sulphadiazine and trimethoprim (T-S) was compared with that of a placebo in the treatment of 75 men with nongonococcal urethritis (NGU) and their female sexual partners. Forty (53%) men and 30 (40%) women had positive culture results for Chlamydia trachomatis before treatment was started. Thirty-four patients of each sex received active treatment. Of these, 19 men and 15 women had positive culture results for C trachomatis before treatment with T-S and one of each sex had a positive culture result after treatment. C trachomatis had been isolated in 21 men and 15 women before treatment with placebo. At follow up four weeks after treatment had been started, 16 men and 15 women still harboured C trachomatis. Five of the chlamydia-positive patients treated with placebo developed complications (epididymitis, arthritis, or salpingitis) so the trial was discontinued.
摘要
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1
Frequent association of chlamydial infection with Reiter's syndrome.
Sex Transm Dis. 1978 Apr-Jun;5(2):57-61. doi: 10.1097/00007435-197804000-00004.
2
Treatment of gonorrhoea with trimethoprim-sulphamethoxazole in Uganda.
Br J Vener Dis. 1970 Jun;46(3):214-6. doi: 10.1136/sti.46.3.214.
3
Trimethoprim-sulphamethoxazole in the treatment of non-gonococcal urethritis and gonorrhoea.
Br J Vener Dis. 1970 Feb;46(1):31-3. doi: 10.1136/sti.46.1.31.
4
Sulphamethoxazole combined with 2-4-diamino-pyrimidines in the treatment of gonorrhoea.
Br J Vener Dis. 1970 Feb;46(1):34-6. doi: 10.1136/sti.46.1.34.
5
Treatment of gonorrhoea with sulphamethoxazole-trimethoprim. Lack of effect on concomitant syphilis.
Br J Vener Dis. 1973 Feb;49(1):50-3. doi: 10.1136/sti.49.1.50.
6
Cotrimoxazole in the treatment of non-gonococcal urethritis.
Acta Derm Venereol. 1974;54(4):317-20.
7
Trimethoprim-sulphamethoxazole in gonorrhoea.
Acta Derm Venereol. 1971;51(5):394-6.
8
Non-specific urethritis and the tetracyclines.
Br J Vener Dis. 1975 Jun;51(3):198-205. doi: 10.1136/sti.51.3.198.
9
Antimicrobial activity of several antibiotics and a sulfonamide against Chlamydia trachomatis organisms in cell culture.
Antimicrob Agents Chemother. 1977 Jul;12(1):80-3. doi: 10.1128/AAC.12.1.80.
10
Non-specific urethritis. A placebo-controlled trial of minocycline in conjunction with laboratory investigations.
Br J Vener Dis. 1976 Aug;52(4):269-75. doi: 10.1136/sti.52.4.269.
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