Fushimi H, Nonaka K, Tarui S, Tochino Y, Kanaya H
Diabetologia. 1980 Jul;19(1):50-3. doi: 10.1007/BF00258311.
Spontaneously diabetic non-obese mice of the ICR strain were newly inbred in Shionogi laboratory, Japan. Animals became diabetic suddenly, more frequently and severely in females. Blood glucose levels were 452 +/- 73 mg/100 ml with serum insulin levels of less than 1.0 microU/ml in the fed state. Parabiosis with normal control ICR mice for 2 weeks decreased the blood glucose level to 260 +/- 51 mg/100 ml (P less than 0.01) and resulted in serum insulin levels of 46.0 +/- 18.0 microU/ml (P less than 0.01). Kidney homogenate beta-N-acetylglucosaminidase and beta-galactosidase activities were reduced in diabetic mice (42% and 44% decreases respectively) (P less than 0.025 and P less than 0.001), and restored almost to normal after 2 weeks of parabiosis. Renal alpha-mannosidase activity was decreased 43% (P less than 0.001) in the diabetic mice but unaffected by parabiosis. Serum beta-N-acetylglucosaminidase, beta-galactosidase and alpha-glucosidase activities were significantly increased in diabetic mice (179%; 233% and 58% increase respectively) (P less than 0.005, P less than 0.001 and P less than 0.001), and returned to normal with parabiosis.
日本盐野义实验室新培育出ICR品系的自发性糖尿病非肥胖小鼠。这些动物突然患上糖尿病，雌性患病更为频繁且严重。在喂食状态下，血糖水平为452±73mg/100ml，血清胰岛素水平低于1.0微单位/毫升。与正常对照ICR小鼠联体共生2周后，血糖水平降至260±51mg/100ml（P<0.01），血清胰岛素水平升至46.0±18.0微单位/毫升（P<0.01）。糖尿病小鼠肾脏匀浆中的β-N-乙酰氨基葡萄糖苷酶和β-半乳糖苷酶活性降低（分别降低42%和44%）（P<0.025和P<0.001），联体共生2周后几乎恢复正常。糖尿病小鼠肾脏α-甘露糖苷酶活性降低43%（P<0.001），但不受联体共生影响。糖尿病小鼠血清β-N-乙酰氨基葡萄糖苷酶、β-半乳糖苷酶和α-葡萄糖苷酶活性显著升高（分别升高179%、233%和58%）（P<0.005、P<0.001和P<0.001），联体共生后恢复正常。
