Yarkoni E, Rapp H J
Cancer Res. 1979 May;39(5):1518-20.
The influence of mineral oil, squalane, squalene, or peanut oil on the antitumor activity of emulsified Bacillus Calmette-Guérin cell walls or emulsified trehalose-6,6'-dimycolate was studied in mice, each with an established transplant of a syngeneic fibrosarcoma. Each animal received an intratumoral injection of Bacillus Calmette-Guérin cell walls (0.6 mg/mouse) or trehalose-6,6'-dimycolate (0.1 mg/mouse) emulsified in 1 to 10% oil. Emulsions of squalene or squalane but not peanut oil were effective substitutes for mineral oil as carriers of Bacillus Calmette-Guérin cell walls in the treatment of the tumor. Trehalose-6,6'-dimycolate was therapeutically active when it was incorporated in any of these four oils. The number of animals in which tumor regressed completely depended on the concentration of oil in the emulsion.
在已建立同基因纤维肉瘤移植瘤的小鼠中，研究了矿物油、角鲨烷、角鲨烯或花生油对乳化卡介苗细胞壁或乳化海藻糖 - 6,6'-二霉菌酸酯抗肿瘤活性的影响。每只动物接受瘤内注射乳化于1%至10%油中的卡介苗细胞壁（0.6毫克/小鼠）或海藻糖 - 6,6'-二霉菌酸酯（0.1毫克/小鼠）。在肿瘤治疗中，角鲨烯或角鲨烷乳液而非花生油乳液可有效替代矿物油作为卡介苗细胞壁的载体。当海藻糖 - 6,6'-二霉菌酸酯掺入这四种油中的任何一种时，都具有治疗活性。肿瘤完全消退的动物数量取决于乳液中油的浓度。
