大肠杆菌中3,4-二羟基苯乙酸途径对3-和4-羟基苯乙酸的分解代谢。
Catabolism of 3- and 4-hydroxyphenylacetate by the 3,4-dihydroxyphenylacetate pathway in Escherichia coli.
作者信息
Cooper R A, Skinner M A
出版信息
J Bacteriol. 1980 Jul;143(1):302-6. doi: 10.1128/jb.143.1.302-306.1980.
Abstract
Various strains of Escherichia coli (but not strain K-12) were found to grow on 3-hydroxyphenylacetate and 4-hydroxyphenylacetate. Both compounds were catabolized by the same pathway, with 3,4-dihydroxyphenylacetate as a substrate for fission of the benzene nucleus, and with pyruvate and succinate as products. All the necessay enzymes were demonstrated in cell extracts prepared from induced cells but were essentially absent from uninduced cells. Mutants unable to grow on 3- and 4-hydroxyphenylactetate were defective in particular enzymes of the pathway. The characteristics of certain mutants indicated that either uptake or hydroxylation of 3- and 4-hydroxyphenylacetate may involve a common protein component. E. coli also grew on 3,4-hydroxyphenylacetate, with induction of the enzyme necessary for its degradation but not those for the uptake-hydroxylation of 3- and 4-hydroxyphenylacetate.
摘要
已发现多种大肠杆菌菌株（但不包括K-12菌株）能在3-羟基苯乙酸和4-羟基苯乙酸上生长。这两种化合物通过相同的途径进行分解代谢，以3,4-二羟基苯乙酸作为苯核裂变的底物，丙酮酸和琥珀酸作为产物。在从诱导细胞制备的细胞提取物中证实了所有必需的酶，但未诱导的细胞中基本不存在这些酶。无法在3-和4-羟基苯乙酸上生长的突变体在该途径的特定酶中存在缺陷。某些突变体的特征表明，3-和4-羟基苯乙酸的摄取或羟基化可能涉及一种共同的蛋白质成分。大肠杆菌也能在3,4-二羟基苯乙酸上生长，诱导出其降解所需的酶，但不是3-和4-羟基苯乙酸摄取-羟基化所需的酶。
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本文引用的文献
1
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Appl Environ Microbiol. 1978 Nov;36(5):631-8. doi: 10.1128/aem.36.5.631-638.1978.
2
METABOLISM OF P-HYDROXYPHENYLACETIC ACID IN PSEUDOMONAS OVALIS.卵形假单胞菌中对羟基苯乙酸的代谢
Biochim Biophys Acta. 1964 Dec 9;93:483-93. doi: 10.1016/0304-4165(64)90332-0.
3
Oxidation of homogentistic acid by cell-free extracts of a vibrio.一种弧菌的无细胞提取物对尿黑酸的氧化作用。
J Gen Microbiol. 1962 Jun;28:251-6. doi: 10.1099/00221287-28-2-251.
4
Catabolism of aromatic compounds by micro-organisms.微生物对芳香族化合物的分解代谢
Adv Microb Physiol. 1971;6(0):1-46. doi: 10.1016/s0065-2911(08)60066-1.
5
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J Bacteriol. 1973 Jun;114(3):974-9. doi: 10.1128/jb.114.3.974-979.1973.
6
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J Bacteriol. 1972 Nov;112(2):815-23. doi: 10.1128/jb.112.2.815-823.1972.
7
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Adv Microb Physiol. 1973;9(0):89-151.
8
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9
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J Bacteriol. 1974 Oct;120(1):416-23. doi: 10.1128/jb.120.1.416-423.1974.
10
Microbial conversion of p-hydroxyphenylacetic acid to homogentisic acid.对羟基苯乙酸向尿黑酸的微生物转化。
Can J Microbiol. 1972 Aug;18(8):1247-55. doi: 10.1139/m72-193.
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