Beam T R, Allen J C
J Infect Dis. 1980 Jul;142(1):72-6. doi: 10.1093/infdis/142.1.72.
The immune-modulating effects of levamisole were evaluated in vivo in rabbits with experimental meningitis due to Escherichia coli and in vitro in assays of ingestive and digestive functions of polymorphonuclear leukocytes. Intracisternal treatment of rabbits with 0.5 ml of levamisole (400 micrograms/ml) 48 and 24 hr before infection resulted in a longer survival time (mean, 49.3 hr) than either control (mean, 21.3 hr; P < 0.01) or intravenously treated animals (mean, 18.3 hr; P < 0.05). However, treatment of the organism by incubation in levamisole (100 micrograms/ml) resulted in survival times significantly longer than that of intracisternally treated animals (mean, 98.5 hr; P < 0.05). A reduction of 5 logs of viable bacteria 22 hr after infection was noted by previous therapy of either the animal or the bacteria. No antibiotic effect was demonstrated. In vitro studies revealed increased ingestion by polymorphonuclear leukocytes (P < 0.02) and digestion (P < 0.05) of bacteria incubated in levamisole. These results suggest that levamisole may alter the bacteria, enhance killing, and produce salutary in vivo effects.
在因大肠杆菌导致实验性脑膜炎的兔体内以及在多形核白细胞摄取和消化功能测定中对左旋咪唑的免疫调节作用进行了评估。在感染前48小时和24小时对兔进行脑池内注射0.5毫升左旋咪唑（400微克/毫升），其存活时间（平均49.3小时）比对照组（平均21.3小时；P<0.01）或静脉注射治疗的动物（平均18.3小时；P<0.05）更长。然而，在左旋咪唑（100微克/毫升）中孵育该生物体，其存活时间显著长于脑池内注射治疗的动物（平均98.5小时；P<0.05）。在感染后22小时，通过对动物或细菌进行预先治疗，可观察到活细菌数量减少5个对数。未显示出抗生素作用。体外研究表明，在左旋咪唑中孵育的细菌，多形核白细胞对其摄取增加（P<0.02）且消化增强（P<0.05）。这些结果表明，左旋咪唑可能改变细菌、增强杀灭作用并在体内产生有益效果。
