Fuller R K, Williford W O
Alcohol Clin Exp Res. 1980 Jul;4(3):298-301. doi: 10.1111/j.1530-0277.1980.tb04818.x.
Data from a study evaluating the efficacy of disulfiram for the treatment of alcoholism were analyzed by life-table methods. Previous analysis by more commonly used statistical tests showed a trend favoring disulfiram treatment, but the results were not statistically significant. Life-table methods are the appropriate techniques for analyzing longitudinal studies because they evaluate response to treatment over time rather than at one point in time. Analysis of our data using these methods revealed that disulfiram, combined with medical care and counseling, was superior to medical care and counseling alone in 128 men followed for 1 yr. This report demonstrates: (A) the advantage of life-table methods for evaluating treatment outcome data in alcoholism studies; and (B) the importance of disulfiram treatment in alcoholic patients similar to those we studied.
一项评估双硫仑治疗酒精中毒疗效的研究数据采用寿命表法进行了分析。以往通过更常用的统计检验进行的分析显示出双硫仑治疗的一种趋势，但结果无统计学显著性。寿命表法是分析纵向研究的合适技术，因为它们评估的是随时间而非某一时刻对治疗的反应。使用这些方法对我们的数据进行分析后发现，在128名随访1年的男性中，双硫仑联合医疗护理和咨询比单纯医疗护理和咨询更有效。本报告表明：(A)寿命表法在评估酒精中毒研究中的治疗结果数据方面的优势；(B)双硫仑治疗对与我们所研究的类似酒精性患者的重要性。
