Fuller R K, Roth H P
Ann Intern Med. 1979 Jun;90(6):901-4. doi: 10.7326/0003-4819-90-6-901.
One hundred twenty-eight alcoholic men were assigned randomly to receive either a regular dose of disulfiram (250 mg), a pharmacologically inactive dose (1 mg), or no disulfiram. There were no statistically significant differences among the three treatment groups in total abstinence, percentage of drinking days, days worked, family stability (living with same relative), or percent of scheduled appointments kept. However, 21% of those who received the regular dose of disulfiram and 25% who received the pharmacologically inactive dose remained abstinent, whereas only 12% of those who received no disulfiram did so. These results indicate that disulfiram may be of limited value in the treatment of alcoholism, fear of the disulfiram-ethanol reaction is important in preventing drinking, and patients willing to take disulfiram are more likely to be abstinent if given the drug. We also found that complete abstinence correlated significantly with compliance and obtaining employment.
128名男性酗酒者被随机分配，分别接受常规剂量的双硫仑（250毫克）、无药理活性剂量（1毫克）或不接受双硫仑治疗。在完全戒酒、饮酒天数百分比、工作天数、家庭稳定性（与同一亲属同住）或预约就诊的按时就诊率方面，三个治疗组之间没有统计学上的显著差异。然而，接受常规剂量双硫仑治疗的人中有21%、接受无药理活性剂量双硫仑治疗的人中有25%保持了戒酒状态，而未接受双硫仑治疗的人中只有12%做到了戒酒。这些结果表明，双硫仑在治疗酒精中毒方面可能价值有限，对双硫仑-乙醇反应的恐惧在预防饮酒方面很重要，并且愿意服用双硫仑的患者如果服用该药更有可能戒酒。我们还发现，完全戒酒与依从性和就业显著相关。
