Howard D R, Batsakis J G
Science. 1980 Oct 10;210(4466):201-3. doi: 10.1126/science.6997995.
Tumor cell membrane glycoproteins may be involved in the induction of tumor immunity or in the escape of tumors from immunologic defense mechanisms. Forty-four benign and malignant breast lesions were examined for the presence of a carbohydrate precursor antigen (T antigen) of the human blood group system MN. T antigen was demonstrated by means of an immunohistochemical technique to detect tissue binding of peanut agglutinin, a plant lectin, with affinity for T antigen. Malignant breast lesions showed a pattern of T antigen expression different from that of benign breast tissues. A possible role for T antigen in the modulation of the immune response to breast carcinoma is suggested.
肿瘤细胞膜糖蛋白可能参与肿瘤免疫的诱导过程，或在肿瘤逃避免疫防御机制中发挥作用。对44例乳腺良恶性病变进行检测，以确定人类MN血型系统的一种碳水化合物前体抗原（T抗原）是否存在。通过免疫组织化学技术，利用对T抗原有亲和力的植物凝集素——花生凝集素检测组织结合情况，证实了T抗原的存在。乳腺恶性病变显示出与乳腺良性组织不同的T抗原表达模式。这提示T抗原在调节对乳腺癌的免疫反应中可能发挥作用。
