Henry M J, Horwitz C A, Stanley M W
Department of Pathology, Hennepin County Medical Center, Minneapolis, MN 55415.
Diagn Cytopathol. 1987 Dec;3(4):310-3. doi: 10.1002/dc.2840030410.
Numerous studies have employed lectin binding patterns to investigate alterations in cell surface polysaccharide expression associated with malignant transformation. Cytostructural relocalization of peanut lectin (Arachis hypogaea) binding sites from the cell surface to the cytoplasm has been described in breast carcinomas. To investigate the possible utility of peanut lectin binding patterns in the diagnosis of breast fine-needle aspirations, the PNA immunoperoxidase method was applied to smears from a group of 15 benign and malignant breast lesions. Cytostructural relocalization of PNA binding was seen in both benign and malignant breast lesions, indicating that it is of little diagnostic utility in the assessment of malignancy. This finding was noted in both cytologic and histologic preparations.
许多研究采用凝集素结合模式来研究与恶性转化相关的细胞表面多糖表达的变化。在乳腺癌中，已描述了花生凝集素（花生）结合位点从细胞表面到细胞质的细胞结构重新定位。为了研究花生凝集素结合模式在乳腺细针穿刺诊断中的可能效用，将PNA免疫过氧化物酶方法应用于一组15例良性和恶性乳腺病变的涂片。在良性和恶性乳腺病变中均可见PNA结合的细胞结构重新定位，表明其在评估恶性肿瘤方面的诊断效用不大。这一发现在细胞学和组织学制剂中均有记录。
