用伤寒杆菌Ty2的非运动性突变体制备的伤寒疫苗的对照现场试验。
Controlled field trial of a typhoid vaccine prepared with a nonmotile mutant of Salmonella typhi Ty2.
作者信息
Wahdan M H, Sippel J E, Mikhail I A, Rahka A E, Anderson E S, Sparks H A, Cvjetanović B
出版信息
Bull World Health Organ. 1975;52(1):69-73.
Abstract
A controlled field trial was performed in Egypt to evaluate a whole cell typhoid vaccine prepared with a nonmotile mutant of S. typhi Ty2 (TNM1) devoid of flagellar antigen. This vaccine did not elicit an H antibody response, but significant Vi and O agglutinin responses were observed. There were 34 typhoid cases among 21 063 six- to seven-year-old children who received the TNM1 vaccine, and 44 cases among 21 017 children in the control group who received tetanus toxoid. These results suggest that TNM1 vaccine does not provide protection against typhoid fever, and that H antigen may be an important component of an effective vaccine.
摘要
在埃及进行了一项对照现场试验，以评估用缺乏鞭毛抗原的伤寒沙门氏菌Ty2非运动突变株（TNM1）制备的全细胞伤寒疫苗。该疫苗未引发H抗体反应，但观察到显著的Vi和O凝集素反应。在接种TNM1疫苗的21063名6至7岁儿童中，有34例伤寒病例，在接种破伤风类毒素的21017名对照组儿童中，有44例病例。这些结果表明，TNM1疫苗不能预防伤寒热，H抗原可能是有效疫苗的重要组成部分。
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