van Weelden H, Young E, van der Leun J C
Br J Dermatol. 1980 Jul;103(1):1-9. doi: 10.1111/j.1365-2133.1980.tb15831.x.
Four treatments involving light were compared in two series of patients with severe psoriasis. The first series consisted of ten patients, who were treated by the method of paired comparisons. The treatments given were: (1) exposure to fluorescent sunlamps (B); (2) the same, supplemented by fluorescent UV-A lamps (A + B); (3) the same as (2) with the addition of the radiation from germicidal lamps (A + B + C); (4) photochemotherapy with oral 8-MOP followed by UV-A (PUVA); (5) one of the fields served as control, receiving no light at all. The second series consisted of thirty patients. They were treated either with PUVA or with a placebo capsule followed by A + B (pUVAB). The phototherapies examined differed from many previous attempts in that the increments in dose were made sufficiently large to overcome the increasing tolerance of the skin to light during the treatment. It is concluded (a) that phototherapy, if conducted in this way, is as effective as PUVA, and (b) that the effectiveness achieved with the phototherapies examined is due to the light from the fluorescent sunlamps (B).
在两组重度银屑病患者中对四种光疗方法进行了比较。第一组有10名患者，采用配对比较法进行治疗。所给予的治疗方法有：(1) 暴露于荧光太阳灯（B）；(2) 同样的方法，再补充荧光UV - A灯（A + B）；(3) 与(2)相同，但增加杀菌灯的辐射（A + B + C）；(4) 口服8 - MOP后进行UV - A光化学疗法（PUVA）；(5) 其中一个部位作为对照，完全不接受光照。第二组有30名患者。他们要么接受PUVA治疗，要么服用安慰剂胶囊后接受A + B（pUVAB）治疗。所研究的光疗方法与之前的许多尝试不同之处在于，剂量增加幅度足够大，以克服治疗过程中皮肤对光耐受性的增加。得出的结论是：(a) 以这种方式进行的光疗与PUVA一样有效；(b) 所研究的光疗方法取得的效果归因于荧光太阳灯发出的光（B）。
