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Treatment of contact hypersensitivity with urocanic acid.

作者信息

van Strien G A, Korstanje M J

机构信息

Department of Dermatology, University Hospital Leiden, The Netherlands.

出版信息

Arch Dermatol Res. 1995;287(6):564-6. doi: 10.1007/BF00374077.

DOI:10.1007/BF00374077
PMID:7487143
Abstract

In order to investigate the effect of cis-urocanic acid (UCA) on a delayed-type hypersensitivity response in humans, a contact hypersensitivity reaction was induced on four test sites on the back of 33 volunteer subjects. The first test site was pretreated with cis-UCA immediately before application of the allergen. The second and third test sites were posttreated on the second and third days of the hypersensitivity response with cis-UCA and a class III corticosteroid, respectively. The fourth test site was used as a positive control. The cutaneous blood flow of the test sites was measured using laser Doppler flowmetry. Pretreatment with cis-UCA reduced the hypersensitivity response significantly. It is possible that cis-UCA could be used in the preventive treatment of contact hypersensitivity responses.

摘要

相似文献

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Arch Dermatol Res. 1995;287(6):564-6. doi: 10.1007/BF00374077.
2
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引用本文的文献

1
cis-urocanic acid is not useful as an immunosuppressive agent in the treatment of human allergic contact dermatitis.顺式尿刊酸在治疗人类过敏性接触性皮炎时，作为免疫抑制剂并无用处。
Arch Dermatol Res. 1996 Oct;288(11):725-7. doi: 10.1007/BF02505286.

本文引用的文献

1
Narrow-band (TL-01) UVB air-conditioned phototherapy for chronic severe adult atopic dermatitis.
Br J Dermatol. 1993 Jan;128(1):49-56. doi: 10.1111/j.1365-2133.1993.tb00147.x.
2
Therapy of psoriasis: comparison of photochemotherapy and several variants of phototherapy.银屑病的治疗：光化学疗法与几种光疗变体的比较。
Br J Dermatol. 1980 Jul;103(1):1-9. doi: 10.1111/j.1365-2133.1980.tb15831.x.
3
Terminology of contact dermatitis.接触性皮炎的术语。
Acta Derm Venereol. 1970;50(4):287-92.
4
Suppression of pathogenesis in cutaneous leishmaniasis by UV irradiation.紫外线照射对皮肤利什曼病发病机制的抑制作用。
Infect Immun. 1986 Mar;51(3):838-43. doi: 10.1128/iai.51.3.838-843.1986.
5
Exposure to low-dose ultraviolet radiation suppresses delayed-type hypersensitivity to herpes simplex virus in mice.暴露于低剂量紫外线辐射会抑制小鼠对单纯疱疹病毒的迟发型超敏反应。
J Invest Dermatol. 1986 Feb;86(2):125-8. doi: 10.1111/1523-1747.ep12284128.
6
Suppression of contact hypersensitivity by short-term ultraviolet irradiation: II. The role of urocanic acid.短期紫外线照射对接触性超敏反应的抑制作用：II. 尿刊酸的作用。
Clin Exp Immunol. 1988 Apr;72(1):174-7.
7
Assessment of erythema in irritant contact dermatitis. Comparison between visual scoring and laser Doppler flowmetry.刺激性接触性皮炎中红斑的评估。视觉评分与激光多普勒血流仪的比较。
Contact Dermatitis. 1988 Mar;18(3):138-42. doi: 10.1111/j.1600-0536.1988.tb04499.x.
8
Systemic administration of urocanic acid generates suppression of the delayed type hypersensitivity response to herpes simplex virus in a murine model of infection.
Photodermatol. 1988 Feb;5(1):9-14.
9
Topical urocanic acid enhances UV-induced tumour yield and malignancy in the hairless mouse.
Photochem Photobiol. 1989 Apr;49(4):459-64. doi: 10.1111/j.1751-1097.1989.tb09195.x.
10
Urocanic acid and immunosuppression.尿刊酸与免疫抑制。
Photochem Photobiol. 1989 Aug;50(2):267-75. doi: 10.1111/j.1751-1097.1989.tb04159.x.