Draper C C, Sirr S S
Br Med J. 1980 Jun 28;280(6231):1575-6. doi: 10.1136/bmj.280.6231.1575.
Sera were obtained in 415 known cases of malaria (88 residents, 327 immigrants) at different times after diagnosis. Three antigens were used in the indirect fluorscence antibody test to detect antibodies to either Plasmodium falciparum or P vivax. Results in residents and immigrants were analysed separately. Most residents had detectable antibodies within one week after an attack, which began to wane after a month. The strongest reactions were obtained in cases of falciparum malaria with the homologous antigen and in cases of vivax malaria with P fieldi. The overall pattern of results was the same in the immigrants but the proportions positive for malaria antibodies, mean titres, persistence of antibodies, and the cross-reaction were usually greater. Testing for malaria antibodies is probably of value in the retrospective differential diagnosis of malaria in patients who have not been exposed to malaria before but must be interpreted with caution in others.
在415例已知疟疾病例（88例本地居民，327例移民）确诊后的不同时间采集血清。采用三种抗原进行间接荧光抗体试验，以检测抗恶性疟原虫或间日疟原虫的抗体。分别分析本地居民和移民的检测结果。大多数本地居民在发病后一周内可检测到抗体，一个月后开始减弱。恶性疟病例使用同源抗原检测时反应最强，间日疟病例使用费氏疟原虫抗原检测时反应最强。移民的总体检测结果模式相同，但疟疾抗体阳性比例、平均滴度、抗体持续时间和交叉反应通常更高。对于既往未接触过疟疾的患者，检测疟疾抗体可能对疟疾的回顾性鉴别诊断有价值，但对其他患者则必须谨慎解读。
