增强酿酒酵母中全能抑制因子效率的同种抑制因子。
Allosuppressors that enhance the efficiency of omnipotent suppressors in Saccharomyces cerevisiae.
作者信息
Song J M, Liebman S W
出版信息
Genetics. 1987 Mar;115(3):451-60. doi: 10.1093/genetics/115.3.451.
Abstract
Two recessive Mendelian-allosuppressors have been isolated and have been shown to enhance the efficiency of omnipotent suppressors thought to be translational ambiguity mutations. These allosuppressors are unlinked to each other or to the omnipotent suppressors on which they act. They also increase the efficiency of the serine-inserting UAA-suppressor, SUP16. One allosuppressor is allelic or tightly linked to the previously isolated sal2. Another allosuppressor, called sal6, represents a new locus, unlinked to the previously isolated sal1-sal5 that enhance the efficiency of the UAA-suppressors. When present singly in the absence of suppressors or other modifiers the sal2 and sal6 mutations do not have suppressor activity. However, when sal2 and sal6 are combined together in a haploid cell they do suppress weakly. In addition sal2 becomes a weak suppressor in the presence of the [eta +] modifying factor.
摘要
已分离出两种隐性孟德尔异源抑制基因，它们被证明可提高被认为是翻译歧义突变的全能抑制基因的效率。这些异源抑制基因彼此之间不连锁，也与它们所作用的全能抑制基因不连锁。它们还提高了插入丝氨酸的UAA抑制基因SUP16的效率。一种异源抑制基因与先前分离出的sal2等位或紧密连锁。另一种异源抑制基因称为sal6，代表一个新位点，与先前分离出的增强UAA抑制基因效率的sal1-sal5不连锁。当单独存在且不存在抑制基因或其他修饰因子时，sal2和sal6突变没有抑制活性。然而，当sal2和sal6在单倍体细胞中组合在一起时，它们确实有微弱的抑制作用。此外，在存在[eta +]修饰因子的情况下，sal2会成为一个弱抑制基因。
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