Ho K, Garancis J C, Paegle R D, Gerber M A, Borkowski W J
Acta Neuropathol. 1980;52(1):81-3. doi: 10.1007/BF00687233.
Progressive multifocal leukoencephalopathy and malignant lymphoma of the brain were noted at postmortem examination in a 68-year-old white woman who was treated with immunosuppressive agents after renal transplantation. The two diseases are not uncommon in patients with immunodeficiency, but their occurrence in the same patient is extremely rare. This association suggests the oncogenicity of papova viruses in man. However, no papovavirus was demonstrated in the tumor by electron microscopy and immunohistochemical staining. The immunohistochemical staining of routine histology sections for the common antigen of polyomaviruses by the peroxidase anti-peroxidase technique is shown to be simple and specific for the detection of polyomaviruses in the demyelinated areas of progressive multifocal leukoencephalopathy.
一名68岁白人女性在肾移植后接受免疫抑制剂治疗，尸检时发现患有进行性多灶性白质脑病和脑恶性淋巴瘤。这两种疾病在免疫缺陷患者中并不罕见，但在同一患者中同时出现极为罕见。这种关联提示乳头多瘤空泡病毒在人类具有致癌性。然而，通过电子显微镜和免疫组织化学染色在肿瘤中未发现乳头多瘤空泡病毒。采用过氧化物酶抗过氧化物酶技术对常规组织学切片进行多瘤病毒共同抗原的免疫组织化学染色，结果表明该方法对于检测进行性多灶性白质脑病脱髓鞘区域的多瘤病毒简单且具有特异性。
