Awadzi K, Gilles H M
Ann Trop Med Parasitol. 1980 Apr;74(2):199-210. doi: 10.1080/00034983.1980.11687331.
In a single-blind comparative study of diethylcarbamazine (DEC) and metrifonate against onchocerciasis, 20 patient received a total dose of 6.6 g DEC over a two-week period and 20 patients each received one dose of metrifonate 10 mg/kg body weight at ten-day intervals, three times. Both the efficacy and the severity of reaction to treatment were measured. DEC proved the more effective, destroying 98.9% of the microfilarial load while metrifonate destroyed only 75.4% (assessed one week after completion of treatment). The reaction to treatment was much more severe in patients treated with DEC. The persistence of significant postural cardiovascular effects for two weeks after the completion of DEC needs to be considered in mass therapy. The pattern of re-emergence of skin microfilariae indicated no difference between the two drugs over a six-month period. It is concluded that DEC is more effective than metrifonate and remains the 'reference' microfilaricide although its effects are more severe than those of metrifonate.
在一项针对盘尾丝虫病的乙胺嗪（DEC）和敌百虫的单盲对照研究中，20名患者在两周内接受了总量为6.6克的乙胺嗪，20名患者每隔十天各接受一剂10毫克/千克体重的敌百虫，共三次。对治疗的疗效和反应严重程度均进行了测量。结果证明乙胺嗪更有效，能消灭98.9%的微丝蚴负荷，而敌百虫仅消灭75.4%（在治疗结束一周后评估）。接受乙胺嗪治疗的患者对治疗的反应要严重得多。在群体治疗中，需要考虑乙胺嗪治疗结束后两周内显著的体位性心血管效应持续存在的情况。皮肤微丝蚴重新出现的模式表明，在六个月的时间里，两种药物之间没有差异。得出的结论是，乙胺嗪比敌百虫更有效，尽管其效果比敌百虫更严重，但它仍然是“标准”的微丝蚴杀虫剂。
