甲苯达唑和敌百虫治疗盘尾丝虫病的进一步试验。
Further trials of mebendazole and metrifonate in the treatment of onchocerciasis.
作者信息
Kale O O
出版信息
Bull World Health Organ. 1982;60(1):109-13.
Abstract
In clinical drug trials, mebendazole, given in various daily doses for up to 14 days to a maximum total of 16.8 g, was found to be ineffective against both adult Onchocerca volvulus and the microfilariae. Metrifonate, however, given in doses of 100 mg daily for 14 days or as four doses of 10 mg/kg of body weight either on alternate days or at weekly intervals showed moderate activity against the microfilariae but none against the adult worm.
摘要
在临床药物试验中，发现甲苯达唑以不同日剂量给药长达14天，总剂量最高达16.8克，对旋盘尾丝虫成虫和微丝蚴均无效。然而，美曲膦酯以每日100毫克的剂量给药14天，或以10毫克/千克体重的剂量分四次给药，隔日或每周一次，对微丝蚴显示出中等活性，但对成虫无活性。
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