Takayama S, Ishikawa T, Nakajima H, Sato S
Jpn J Cancer Res. 1985 Jun;76(6):457-61.
The carcinogenicity of a potent mutagen, 1,6-dinitropyrene (1,6-DNP), was examined by intratracheal instillation into non-inbred Syrian golden hamsters of both sexes. Animals were treated with 0.5 mg of 1,6-DNP suspended in 0.2 ml of saline intratracheally once a week for 26 weeks. Lung carcinomas developed in experimental weeks 20-48 in 100 and 90%, respectively, of the male and female hamsters treated with 1,6-DNP. Besides lung carcinomas, myeloid leukemias developed in 60% of both males and females treated with 1,6-DNP. No tumors were found in control hamsters.
通过向非近交系叙利亚金黄地鼠两性气管内滴注的方式，对一种强效诱变剂1,6 -二硝基芘（1,6 - DNP）的致癌性进行了研究。动物每周一次气管内滴注悬浮于0.2毫升生理盐水中的0.5毫克1,6 - DNP，持续26周。在实验的第20 - 48周，接受1,6 - DNP治疗的雄性和雌性仓鼠分别有100%和90%发生了肺癌。除肺癌外，接受1,6 - DNP治疗的雄性和雌性仓鼠中均有60%发生了髓性白血病。对照仓鼠未发现肿瘤。
