Cohen H N, Hay I D, Thomson J A, Logue F, Ratcliffe W A, Beastall G H
Clin Endocrinol (Oxf). 1979 Jul;11(1):89-93. doi: 10.1111/j.1365-2265.1979.tb03050.x.
A comparison was made between the growth hormone (GH) response to metoclopramide ('Maxolon'--Beecham Laboratories) and insulin induced hypoglycaemia in thirty-five short adolescent males. Both tests initially caused adequate release of GH from the pituitary gland in 86% of those subjects who had normal GH reserve. The peak growth hormone responses of the two tests were similar in magnitude and were strongly correlated (r = 0.80, P less than 0.001). Both tests raised serum GH to a similar degree in twenty-nine out of the thirty-five boys (83%), but four boys who responded satisfactorily to hypoglycaemia failed to respond to metoclopramide (MCP) stimulation, and two boys who failed to respond to hypoglycaemia responded satisfactorily to MCP stimulation. MCP stimulation does not require prior preparation of the patient and is relatively free of side effects. Consequently, it is suggested that MCP stimulation may be a useful 1 hour out-patient test for growth hormone deficiency in this relatively common group of patients.
对35名青春期男性矮个子进行了对比，观察他们对甲氧氯普胺（“胃复安”——比彻姆实验室出品）和胰岛素诱发低血糖的生长激素（GH）反应。在那些生长激素储备正常的受试者中，这两种测试最初均使86%的受试者垂体充分释放生长激素。两种测试的生长激素峰值反应在幅度上相似且呈强相关（r = 0.80，P < 0.001）。在35名男孩中的29名（83%）中，两种测试使血清生长激素升高到相似程度，但4名对低血糖反应良好的男孩对甲氧氯普胺（MCP）刺激无反应，而2名对低血糖无反应的男孩对MCP刺激反应良好。MCP刺激无需患者预先准备且副作用相对较少。因此，有人提出MCP刺激可能是针对这类相对常见患者群体生长激素缺乏症的一种有用的1小时门诊测试。
