Park T S, Kleinman G M, Richardson E P
Acta Neuropathol. 1980;52(3):239-42. doi: 10.1007/BF00705813.
Degeneration of the white matter is uncommon is Creutzfeldt-Jakob disease (CJD), and when it occurs is usually mild, and limited in distribution. In the case of 77-year-old woman with CJD lasting 1 year, there was extensive degeneration of cerebral white matter in addition to severe loss of neurons and hypertrophic astrogliosis in cortex and striatum. The extent and severity of white matter lesions makes the case unusual.
白质变性在克雅氏病（CJD）中并不常见，一旦发生通常程度较轻，且分布局限。在一名病程1年的77岁克雅氏病女性患者中，除了皮质和纹状体神经元严重缺失及星形胶质细胞增生外，还存在广泛的脑白质变性。白质病变的范围和严重程度使得该病例较为罕见。
