Masters C L, Kakulas B A, Alpers M P, Gajdusek D C, Gibbs C J
J Neuropathol Exp Neurol. 1976 Nov-Dec;35(6):593-605. doi: 10.1097/00005072-197611000-00001.
Creutzfeldt-Jakob disease and kuru were studied in experimental primates. Eight animals with clinical disease lasting from 1/2 to 12 1/2 months were evaluated for histological evidence of progression of the pathological triad of neuronal vacuolation, neuronal loss and fibrous astrocytosis. The first change to appear was neuronal vacuolation, in both the body of neurones and in the neuropil. Fibrous astrocytosis was found subsequent to neuronal damage and necrosis. Neuronal loss was apparent when clinical signs were present. As the clinical disease progressed, so did the severity of neuronal loss and astrocytosis. Five animals, 1 1/2-10 1/2 months after intracerebral inoculation, before they had shown any signs of clinical disease, had histological evidence of neuronal vacuolation and astrocytosis.
在实验性灵长类动物中对克雅氏病和库鲁病进行了研究。对8只患有持续1/2至12 1/2个月临床疾病的动物进行了评估，以寻找神经元空泡化、神经元丧失和纤维性星形细胞增生这一病理三联征进展的组织学证据。首先出现的变化是神经元空泡化，在神经元胞体和神经毡中均有出现。纤维性星形细胞增生在神经元损伤和坏死后被发现。当出现临床体征时，神经元丧失明显。随着临床疾病的进展，神经元丧失和星形细胞增生的严重程度也随之增加。5只动物在脑内接种后1 1/2至10 1/2个月，在出现任何临床疾病体征之前，就有神经元空泡化和星形细胞增生的组织学证据。
