Han S H, Kuo S L, Hu S C, Lu S T
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1980 Jun;13(2):121-7.
The volunteers studied included 6 tuberculoid and 11 lepromatous leprosy patients (Ridley and Jopling). Each received intradermally 0.1 ml of lepromin (Wade method) and 0.1 ml of autoclaved BCG (grown on Dubos medium) at 2 separate sites on the left upper arm. Observations were made at weekly intervals, and biopsy specimens were taken at the fourth wk. Within 3 to 4 wk all 6 tuberculoid patients responded to lepromin with typical granulomas (5 of which measured 5 mm or more in diameter) composed of epithelioid cells, lymphocytes and giant cells. In contrast, 8 of the 11 lepromatous patients remained negative; the other 3 developed tiny papules less than 3 mm in diameter which disappeared after 2 wk. Biopsy specimens taken from injection sities at the fourth wk showed essentially normal histology. All 1 patients developed typical granulomas to heat-killed BCG (non were less than 5 mm in diameter and most were larger) consisting of epithelioid cells, many lymphocytes and a few giant cells. The reaction in tuberculoid leprosy was stronger than that in lepromatous leprosy and the reaction to BCG in tuberculoid leprosy was stronger than that to lepromin, but the differences were not very remarkable.
所研究的志愿者包括6名结核样型麻风患者和11名瘤型麻风患者（里德利和乔普林分类法）。每位患者在左上臂的两个不同部位皮内注射0.1毫升麻风菌素（韦德法）和0.1毫升高压灭菌卡介苗（在杜博斯培养基上培养）。每周进行观察，并在第4周采集活检标本。在3至4周内，所有6名结核样型患者对麻风菌素产生反应，出现由上皮样细胞、淋巴细胞和巨细胞组成的典型肉芽肿（其中5个直径达5毫米或更大）。相比之下，11名瘤型患者中有8名反应阴性；另外3名出现直径小于3毫米的微小丘疹，2周后消失。第4周从注射部位采集的活检标本显示组织学基本正常。所有17名患者对热灭活卡介苗均产生典型肉芽肿（直径均不小于5毫米，多数更大），由上皮样细胞、许多淋巴细胞和少数巨细胞组成。结核样型麻风的反应比瘤型麻风更强，结核样型麻风对卡介苗的反应比对麻风菌素的反应更强，但差异不是很显著。
