Dry J, Pradalier A, Aubry J P, Cheymol G
Pathol Biol (Paris). 1980 Feb;28(2):95-100.
The authors studied variations in histamine and serotonin levels in whole blood, in ten asthmatics with bronchospasm induced by running. A significant elevation of histamine following exercise was noted both in the asthmatics and in the control group and the difference in histamine levels in the two groups is then significant. However no correlation was found between the level of histamine before or after exercise and bronchospasm or the intensity of the drop in FEV1. This is also true of serotonine. The changes in level of these amines thus seem top play a minimal role in the initiation and intensity of exercise induced bronchospasm in asthmatics.
作者研究了10名因跑步诱发支气管痉挛的哮喘患者全血中组胺和血清素水平的变化。哮喘患者和对照组在运动后组胺水平均显著升高，两组间组胺水平差异显著。然而，运动前后组胺水平与支气管痉挛或第一秒用力呼气量（FEV1）下降强度之间均未发现相关性。血清素情况亦是如此。因此，这些胺类水平的变化在哮喘患者运动诱发支气管痉挛的起始和强度方面似乎起的作用极小。
