[Histamine and serotonin levels in exercise induced bronchospasm in asthmatics (author's transl)].

The authors studied variations in histamine and serotonin levels in whole blood, in ten asthmatics with bronchospasm induced by running. A significant elevation of histamine following exercise was noted both in the asthmatics and in the control group and the difference in histamine levels in the two groups is then significant. However no correlation was found between the level of histamine before or after exercise and bronchospasm or the intensity of the drop in FEV1. This is also true of serotonine. The changes in level of these amines thus seem top play a minimal role in the initiation and intensity of exercise induced bronchospasm in asthmatics.