Slocombe G W, Berry C L, Swettenham K V
Virchows Arch A Pathol Anat Histol. 1980;387(3):289-300. doi: 10.1007/BF00454832.
In this study the immunoperoxidase technique was used to demonstrate the blood group antigens A, B and H in normal gastric mucosa and primary and metastatic gastric carcinomas. No clear relationship between tumour differentiation and preservation of blood group antigens was found. In some well differentiated tumours there was a marked loss of blood group substance, whereas in other poorly differentiated tumours, both primary and metastatic, it was easily detectable. In some tumours an inverse relationship between A or B and H activity was noted. This observation is consistent with the theory that in some malignant cells there is a blocking of the normal step-by-step elongation of the carbohydrate portion of blood group substances.
在本研究中，采用免疫过氧化物酶技术来显示正常胃黏膜、原发性和转移性胃癌中的血型抗原A、B和H。未发现肿瘤分化与血型抗原保留之间存在明确关系。在一些高分化肿瘤中，血型物质明显缺失，而在其他低分化肿瘤（包括原发性和转移性）中，却很容易检测到血型物质。在一些肿瘤中，观察到A或B与H活性之间呈负相关。这一观察结果与以下理论相符：在一些恶性细胞中，血型物质碳水化合物部分的正常逐步延长过程受到了阻碍。
