在致敏淋巴细胞分型中缺乏非HLA抗原的再次刺激。

Lack of restimulation by non-HLA antigens in primed lymphocyte typing.

作者信息

Shih C Y, Valentine E A, Sheehy M J, Sondel P M, Bach F H

出版信息

Scand J Immunol. 1977;6(5):501-5. doi: 10.1111/j.1365-3083.1977.tb02111.x.

DOI:10.1111/j.1365-3083.1977.tb02111.x

Abstract

We have studied the role of non-HLA antigens in restimulation of PLT cells by the following protocols. Responder cells were sensitized to cells from family members differing by one HLA haplotype. The PLT cells were restimulated by family members HLA- or HLA-D-identical to the responder. In none of these cases did we find significant restimulation, indicating that it is unlikely that there is a restimulatory non-HLA locus with even two alleles (p less than 0.05) of equal frequency. Other protocols we have used are consistent with this interpretation. This indicates that antigens determined by genes segregating independently of HLA do not play a major role in the PLT restimulation.

摘要

我们通过以下方案研究了非HLA抗原在PLT细胞再刺激中的作用。应答细胞对来自一个HLA单倍型不同的家庭成员的细胞产生致敏。PLT细胞由与应答者HLA或HLA-D相同的家庭成员进行再刺激。在这些情况中，我们均未发现明显的再刺激，这表明不太可能存在一个具有两个等频率等位基因（p小于0.05）的再刺激非HLA基因座。我们使用的其他方案也与这一解释一致。这表明由独立于HLA分离的基因所决定的抗原在PLT再刺激中不起主要作用。