日本人群中的HLA - D抗原。

HLA-D antigens in the Japanese population.

作者信息

Sasazuki T, McMichael A, Payne R, McDevitt H O

出版信息

Tissue Antigens. 1977 May;9(5):267-72. doi: 10.1111/j.1399-0039.1977.tb01117.x.

DOI:10.1111/j.1399-0039.1977.tb01117.x

Abstract

A Japanese population was typed for HLA-D antigens for the first time using HLA-D homozygous typing cells Dw1 through Dw4 and the homozygous cells LD HO and LD AH, newly found in the Japanese population. Dw3 was absent from the Japanese population which also lacks B8. Dw1, Dw2 and Dw4 were found in this population, but these did not show significant linkage disequilibria with any alleles of the B or C loci. LD HO and LD AH were common in Japanese but absent in Caucasians. LD HO was found to be in strong linkage disequilibrium with Bw35. LD AH showed significant association with Bw22J.

摘要

首次使用HLA-D纯合分型细胞Dw1至Dw4以及在日本人群中新发现的纯合细胞LD HO和LD AH对日本人群进行HLA-D抗原分型。日本人群中不存在Dw3，该人群也缺乏B8。在该人群中发现了Dw1、Dw2和Dw4，但它们与B或C位点的任何等位基因均未显示出显著的连锁不平衡。LD HO和LD AH在日本人中很常见，但在高加索人中不存在。发现LD HO与Bw35存在强连锁不平衡。LD AH与Bw22J显示出显著关联。