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1
Rheumatoid factors in mice: plaque assay for homophile and heterophile rheumatoid factors.小鼠中的类风湿因子：嗜同种和嗜异性类风湿因子的空斑测定
Immunology. 1980 Nov;41(3):569-77.
2
Rheumatoid factors in mice: non-specific activators of heterophile rheumatoid factor production.小鼠中的类风湿因子：嗜异性类风湿因子产生的非特异性激活剂。
Immunology. 1980 Nov;41(3):579-85.
3
Secretion of IgM-rheumatoid factor and IgM by blood lymphocytes in rheumatoid arthritis.类风湿关节炎中血液淋巴细胞分泌IgM类风湿因子和IgM
Acta Pathol Microbiol Immunol Scand C. 1983 Feb;91(1):27-33.
4
IgM rheumatoid factors in mice injected with bacterial lipopolysaccharides.注射细菌脂多糖的小鼠体内的IgM类风湿因子
J Immunol. 1979 May;122(5):2096-102.
5
Preferential induction of autoantibody secretion in polyclonal activation by peptidoglycan and lipopolysaccharide. I. In vitro studies.肽聚糖和脂多糖在多克隆激活中对自身抗体分泌的优先诱导作用。I. 体外研究。
J Immunol. 1982 Mar;128(3):1018-25.
6
Induction of rheumatoid factors in mice by immune complexes of bacterial lipopolysaccharide with mouse IgG antibody.细菌脂多糖与小鼠IgG抗体的免疫复合物在小鼠体内诱导类风湿因子的产生。
Eur J Immunol. 1986 Jan;16(1):63-8. doi: 10.1002/eji.1830160113.
7
Neutral proteinases induce rheumatoid factor production in mouse spleen cell cultures.中性蛋白酶在小鼠脾细胞培养物中诱导类风湿因子的产生。
Clin Exp Immunol. 1984 Jan;55(1):99-105.
8
Limitations of a hemolytic plaque assay for IgG-anti-IgG rheumatoid factor-producing cells.用于检测产生IgG抗IgG类风湿因子细胞的溶血空斑试验的局限性。
J Immunol Methods. 1987 Sep 24;102(2):195-204. doi: 10.1016/0022-1759(87)90077-9.
9
Plaque-forming cell response in BALB/c mice to two preparations of LPS extracted from Salmonella enteritidis.BALB/c小鼠对从肠炎沙门氏菌中提取的两种脂多糖制剂的空斑形成细胞反应。
J Immunol. 1979 Apr;122(4):1290-3.
10
Preferential induction of autoantibody secretion in polyclonal activation by peptidoglycan and lipopolysaccharide. II. In vivo studies.肽聚糖和脂多糖在多克隆激活中对自身抗体分泌的优先诱导作用。II. 体内研究。
J Immunol. 1982 Mar;128(3):1026-30.

引用本文的文献

1
A flow microfluorimetric analysis of the binding of immunoglobulins to Fc gamma receptors on brush borders of the neonatal mouse jejunal epithelium.新生小鼠空肠上皮刷状缘上免疫球蛋白与Fcγ受体结合的流式微荧光分析。
Immunology. 1984 Mar;51(3):529-33.
2
Pregnancy induces an increase in the number of immunoglobulin-secreting cells.怀孕会导致分泌免疫球蛋白的细胞数量增加。
Immunology. 1983 Jul;49(3):481-90.
3
Pretreatment of mice with anti-IgD serum does not result in suppression of immune responsiveness induced by TNP-AECM-Ficoll or lipopolysaccharide.用抗IgD血清对小鼠进行预处理不会导致对由三硝基苯 - 抗原提取细胞基质 - 聚蔗糖（TNP - AECM - Ficoll）或脂多糖诱导的免疫反应性的抑制。
Immunology. 1983 Mar;48(3):497-501.
4
Rheumatoid factors in mice: non-specific activators of heterophile rheumatoid factor production.小鼠中的类风湿因子：嗜异性类风湿因子产生的非特异性激活剂。
Immunology. 1980 Nov;41(3):579-85.
5
Interleukin 4 (B-cell growth factor II/eosinophil differentiation factor) is a mitogen and differentiation factor for preactivated murine B lymphocytes.白细胞介素4（B细胞生长因子II/嗜酸性粒细胞分化因子）是预激活的小鼠B淋巴细胞的促有丝分裂因子和分化因子。
Proc Natl Acad Sci U S A. 1986 Jul;83(14):5228-32. doi: 10.1073/pnas.83.14.5228.

本文引用的文献

1
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
2
Occurence and properties of rabbit IgG1 antibody.兔IgG1抗体的发生与特性
J Immunol. 1969 Mar;102(3):713-9.
3
Competition of 19S and 7S antigen receptors in the regulation of the primary immune response.19S和7S抗原受体在初次免疫反应调节中的竞争
J Exp Med. 1968 Jul 1;128(1):133-52. doi: 10.1084/jem.128.1.133.
4
The effect of pertussis vaccine on the immune response of mice to sheep red blood cells.百日咳疫苗对小鼠针对绵羊红细胞免疫反应的影响。
Clin Exp Immunol. 1970 Dec;7(6):817-31.
5
Biological activities of immunoglobulins of different classes and subclasses.不同类别和亚类免疫球蛋白的生物学活性
Adv Immunol. 1974;19(0):259-94. doi: 10.1016/s0065-2776(08)60254-0.
6
Antibody coated erythrocytes as a manifold probe for antigens.抗体包被红细胞作为抗原的多用途探针。
Nature. 1974 Apr 5;248(448):515-7. doi: 10.1038/248515a0.
7
Assignment of direct and facilitated hemolytic plaques in mice to specific immunoglobulin classes.小鼠中直接溶血斑和易化溶血斑向特定免疫球蛋白类别的分配。
J Immunol. 1968 Apr;100(4):744-51.
8
Antigenic determinants specific for aggregated gamma G-globulins.针对聚合γ-球蛋白的抗原决定簇。
J Immunol. 1968 Apr;100(4):718-25.
9
Towards a network theory of the immune system.迈向免疫系统的网络理论。
Ann Immunol (Paris). 1974 Jan;125C(1-2):373-89.
10
Specific suppression of immune responses.免疫反应的特异性抑制
Science. 1973 Sep 21;181(4105):1133-41. doi: 10.1126/science.181.4105.1133.

小鼠中的类风湿因子：嗜同种和嗜异性类风湿因子的空斑测定

Rheumatoid factors in mice: plaque assay for homophile and heterophile rheumatoid factors.

作者信息

Dresser D W, Popham A M

出版信息

Immunology. 1980 Nov;41(3):569-77.

PMID:7007211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458158/
Abstract

It was found that a high proportion of IgM-producing cells secrete homophile or heterophile rheumatoid factors (RF). Injection of lipopolysaccharide (LPS) into CBA mice resulted in a sharp increase in total IgM and in RF-producing cells and in some cases resulted in an increase in RF-producing cells as a proportion of total IgM. RF plaques are indirect IgM in the sense that they require development by IgG2 (anti-IgM) antibody for visualization in a standard haemolytic plaque assay. The RF response to LPS is both dose- and time-dependent.

摘要

研究发现，高比例产生IgM的细胞分泌亲同种抗体或亲异种抗体类风湿因子（RF）。向CBA小鼠注射脂多糖（LPS）导致总IgM和产生RF的细胞急剧增加，在某些情况下，产生RF的细胞占总IgM的比例增加。RF噬斑是间接IgM，因为在标准溶血噬斑试验中，它们需要IgG2（抗IgM）抗体的作用才能显现。对LPS的RF反应具有剂量和时间依赖性。