小鼠中的类风湿因子：嗜同种和嗜异性类风湿因子的空斑测定
Rheumatoid factors in mice: plaque assay for homophile and heterophile rheumatoid factors.
作者信息
Dresser D W, Popham A M
出版信息
Immunology. 1980 Nov;41(3):569-77.
Abstract
It was found that a high proportion of IgM-producing cells secrete homophile or heterophile rheumatoid factors (RF). Injection of lipopolysaccharide (LPS) into CBA mice resulted in a sharp increase in total IgM and in RF-producing cells and in some cases resulted in an increase in RF-producing cells as a proportion of total IgM. RF plaques are indirect IgM in the sense that they require development by IgG2 (anti-IgM) antibody for visualization in a standard haemolytic plaque assay. The RF response to LPS is both dose- and time-dependent.
摘要
研究发现，高比例产生IgM的细胞分泌亲同种抗体或亲异种抗体类风湿因子（RF）。向CBA小鼠注射脂多糖（LPS）导致总IgM和产生RF的细胞急剧增加，在某些情况下，产生RF的细胞占总IgM的比例增加。RF噬斑是间接IgM，因为在标准溶血噬斑试验中，它们需要IgG2（抗IgM）抗体的作用才能显现。对LPS的RF反应具有剂量和时间依赖性。
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