Gove C D, Wardle E N, Williams R
J Clin Pathol. 1981 Jan;34(1):13-6. doi: 10.1136/jcp.34.1.13.
The activities of the lysosomal enzymes acid and neutral protease, N-acetylglucosaminidase, and acid phosphatase were measured in the serum of patients with fulminant hepatic failure. Acid protease (cathepsin D) activity was increased about tenfold in patients who died and nearly fourfold in those who survived fulminant hepatic failure after paracetamol overdose, whereas activities were increased equally in patients with fulminant hepatic failure due to viral hepatitis whether or not they survived. A correlation was found between serum acid protease activity and prothrombin time, and the increase in cathepsin D activity was sustained over several days compared with aspartate aminotransferase, which showed a sharp early peak and then a fall. Circulating lysosomal proteases can damage other organs, and measurement of their activity may therefore be of added value in assessing prognosis in this condition.
对暴发性肝衰竭患者的血清进行了溶酶体酶（酸性和中性蛋白酶、N-乙酰葡糖胺酶及酸性磷酸酶）活性检测。在对乙酰氨基酚过量导致暴发性肝衰竭后死亡的患者中，酸性蛋白酶（组织蛋白酶D）活性增加约10倍，存活患者中该活性增加近4倍；而在因病毒性肝炎导致暴发性肝衰竭的患者中，无论存活与否，该酶活性均有同等程度增加。血清酸性蛋白酶活性与凝血酶原时间之间存在相关性，与天冬氨酸氨基转移酶相比，组织蛋白酶D活性的增加可持续数天，天冬氨酸氨基转移酶在早期出现急剧峰值后便下降。循环中的溶酶体蛋白酶可损害其他器官，因此，检测其活性可能对评估该病症的预后具有额外价值。
