Mathur S, Melchers J T, Ades E W, Williamson H O, Fudenberg H H
J Reprod Immunol. 1980 Dec;2(5):247-62. doi: 10.1016/0165-0378(80)90038-8.
Seventeen of 30 patients with chronic vaginal candidiasis (CVC) of at least 5 years duration had varying degrees of menstrual problems and defective T lymphocyte function; 8 developed amenorrhea. In a group of 40 CVC patients, titers of autoantibodies to ovary, thymocytes, a T-cell line (CCRF-CEM), and a B-cell line (RN114) were significantly higher than those in 45 normal females (69 +/- 3 vs. 5 +/- 2, 70 +/- 27 vs. 4 +/- 2, l7 +/- 6, vs. 4 +/ 2, and 73 +/- 24 vs. 8 +/- 5, respectively, mean +/- S.E.). Antibody titers to sperm, T-cell line HSB-2, and B-cell lines RAJI and BALL-1 were within the normal range. Significant correlations were found between anti-Candida, anti-ovarian, and anti-thymocyte antibody titers. Similar results were found for 6 patients with chronic mucocutaneous candidiasis (CMCC) and in serial samples obtained over a one-year period from a representative patient with both CVC and CMCC. The anti-T-lymphocyte antibodies in these patients were directed primarily against non-suppressor (predominately helper) T cells. Absorption of the sera with either Candida cells, ovarian follicle cells, or thymocytes reduced all three antibody titers; absorption with sperm or B-cell lines did not alter the titers. These results suggest the presence of one or more cross-reactive antigens on ovarian follicle, T lymphocytes (especially the helper cell subpopulation), and Candida.
30例病程至少5年的慢性阴道念珠菌病（CVC）患者中有17例存在不同程度的月经问题及T淋巴细胞功能缺陷；8例出现闭经。在一组40例CVC患者中，针对卵巢、胸腺细胞、一种T细胞系（CCRF - CEM）和一种B细胞系（RN114）的自身抗体滴度显著高于45名正常女性（分别为69±3对5±2、70±27对4±2、17±6对4±2、73±24对8±5，均值±标准误）。针对精子、T细胞系HSB - 2以及B细胞系RAJI和BALL - 1的抗体滴度在正常范围内。抗念珠菌、抗卵巢和抗胸腺细胞抗体滴度之间存在显著相关性。6例慢性黏膜皮肤念珠菌病（CMCC）患者以及一名同时患有CVC和CMCC的代表性患者在一年期间采集的系列样本中也发现了类似结果。这些患者体内的抗T淋巴细胞抗体主要针对非抑制性（主要是辅助性）T细胞。用念珠菌细胞、卵巢卵泡细胞或胸腺细胞吸收血清可降低所有这三种抗体滴度；用精子或B细胞系吸收则不会改变滴度。这些结果表明在卵巢卵泡、T淋巴细胞（尤其是辅助性细胞亚群）和念珠菌上存在一种或多种交叉反应性抗原。
